Reversal of Chronic Diabetes Insipidus During Treatment With Protriptyline
| Autor: | Clark Rw, Schmidt Hs, Sotos Jf |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Sleep Wake Disorders Adolescent Cataplexy medicine.drug_class business.industry Remission Spontaneous Sleep apnea Tricyclic antidepressant Dibenzocycloheptenes General Medicine Protriptyline medicine.disease Discontinuation Anesthesia Chronic Disease Diabetes insipidus medicine Humans medicine.symptom business Diabetes Insipidus medicine.drug |
| Zdroj: | Southern Medical Journal. 71:1567-1568 |
| ISSN: | 0038-4348 |
| Popis: | We have described a 13-year-old white boy with Ondine's curse, sleep apnea and cataplexy who simultaneously developed progressive hypothalamic neuroendocrine deficiencies requiring replacement therapy. The patient was treated with protriptyline, a nonsedating tricyclic antidepressant, for control of the sleep-related symptoms. An unexpected result was the apparent reversal of his chronic diabetes insipidus by protriptyline, necessitating discontinuation of lysine-vasopressin. Some possible mechanisms of action were discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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