Sugar transporters for intercellular exchange and nutrition of pathogens
| Autor: | Sylvie Lalonde, Wolf B. Frommer, William Underwood, Shauna Somerville, Diane Chermak, Hitomi Takanaga, Ginny Antony, Li Qing Chen, Jung Gun Kim, Mary Beth Mudgett, Frank F. White, Mara L. Hartung, Woei Jiun Guo, Xiao Qing Qu, Bhavna Chaudhuri, Bi Huei Hou |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Xenopus
Arabidopsis Saccharomyces cerevisiae Models Biological Article Gene Expression Regulation Plant Animals Humans Arabidopsis thaliana RNA Messenger Sugar transporter Sugar Multidisciplinary biology Arabidopsis Proteins Effector Gene Expression Profiling Intercellular transport Glucose transporter Membrane Transport Proteins food and beverages Biological Transport Oryza biology.organism_classification Glucose HEK293 Cells Biochemistry Host-Pathogen Interactions Efflux |
| Popis: | Sugar efflux transporters are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. Despite broad biological importance, the identity of sugar efflux transporters has remained elusive. Using optical glucose sensors, we identified a new class of sugar transporters, named SWEETs, and show that at least six out of seventeen Arabidopsis, two out of over twenty rice and two out of seven homologues in Caenorhabditis elegans, and the single copy human protein, mediate glucose transport. Arabidopsis SWEET8 is essential for pollen viability, and the rice homologues SWEET11 and SWEET14 are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter. Bacterial symbionts and fungal and bacterial pathogens induce the expression of different SWEET genes, indicating that the sugar efflux function of SWEET transporters is probably targeted by pathogens and symbionts for nutritional gain. The metazoan homologues may be involved in sugar efflux from intestinal, liver, epididymis and mammary cells. |
| Databáze: | OpenAIRE |
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