A prospective evaluation of thiamine and magnesium status in relation to clinicopathological characteristics and 1-year mortality in patients with Alcohol Withdrawal Syndrome

Autor: Alana Burns, Ewan Forrest, Fiona Stefanowicz, Lesley Orr, Michael Adamson, Dinesh Talwar, David P. Ross, Xen Roussis, David Young, Peter Galloway, Donald C. McMillan, Hannah Bell, Gordon Robson, Donogh Maguire, Anthony Catchpole, Joanna-Lee Kerr, Eoghan Colgan, Alastair J Ireland
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
Serum magnesium concentration
chemistry.chemical_element
lcsh:Medicine
Gastroenterology
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
QA273
Internal medicine
medicine
Humans
Alcohol withdrawal syndrome (AWS)
Magnesium
030212 general & internal medicine
Prospective Studies
Thiamine
Whole blood
Circulating thiamine diphosphate (TDP)
Hematology
business.industry
Mortality rate
Research
lcsh:R
General Medicine
Emergency department
Plasma lactate concentrations
Middle Aged
medicine.disease
Pathophysiology
Substance Withdrawal Syndrome
Alcoholism
Seizure kindling
Pseudo-hypoxia
Glasgow modified alcohol withdrawal scale (GMAWS)
chemistry
Alcohol withdrawal syndrome
1-year mortality
Female
business
030217 neurology & neurosurgery
Zdroj: Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-13 (2019)
Journal of Translational Medicine
ISSN: 1479-5876
Popis: Background Alcohol withdrawal syndrome (AWS) is routinely treated with B-vitamins. However, the relationship between thiamine status and outcome is rarely examined. The aim of the present study was to examine the relationship between thiamine and magnesium status in patients with AWS. Methods Patients (n = 127) presenting to the Emergency Department with AWS were recruited to a prospective observational study. Blood samples were drawn to measure whole blood thiamine diphosphate (TDP) and serum magnesium concentrations. Routine biochemistry and haematology assays were also conducted. The Glasgow Modified Alcohol Withdrawal Score (GMAWS) measured severity of AWS. Seizure history and current medications were also recorded. Results The majority of patients (99%) had whole blood TDP concentration within/above the reference interval (275–675 ng/gHb) and had been prescribed thiamine (70%). In contrast, the majority of patients (60%) had low serum magnesium concentrations (2 (p Conclusion The prevalence of low circulating thiamine concentrations were rare and it was regularly prescribed in patients with AWS. In contrast, low serum magnesium concentrations were common and not prescribed. Low serum magnesium was associated more severe AWS and increased 1-year mortality.
Databáze: OpenAIRE
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