Incidence and mortality of myeloid malignancies in children, adolescents and Young adults in Brazil: A population-based study
| Autor: | Berenice Navarro Antoniazzif, Suellen Valadares Moura Feliciano, Donaldo Botelho Venezian, José Carlo de Oliveira, Terezinha Almeida de Aquino, Lucrecia Aline Cabral Formigosa, Marceli de Oliveira Santos, Cyntia Asturian Laporte, Adriana de Souza, Paulo Cesar Fernandes de Souza, Larissa Dell’Antonio Pereira, Carlos Anselmo Lima, Josefa Ângela Pontes de Aquino, Allini Mafra da Costa, Nayara Cabral Machado, Miren Maite Uribe Arregi, Cristina Maria Almeida dos Santos, Maria S. Pombo-de-Oliveira |
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| Rok vydání: | 2019 |
| Předmět: |
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Cancer Research Adolescent Epidemiology Population 03 medical and health sciences 0302 clinical medicine Humans Medicine Registries 030212 general & internal medicine Young adult Child education education.field_of_study Myeloproliferative Disorders business.industry Incidence Mortality rate Incidence (epidemiology) Not Otherwise Specified Infant Newborn Infant Annual Percent Change Cancer registry Oncology Child Preschool 030220 oncology & carcinogenesis Etiology Female business Brazil Demography |
| Zdroj: | Cancer Epidemiology. 62:101583 |
| ISSN: | 1877-7821 |
| DOI: | 10.1016/j.canep.2019.101583 |
| Popis: | Background Myeloid malignancies (MM) are heterogeneous when it comes to incidence rates and pathogenesis. These variation rates are important to generate hypotheses on causal aetiology. This study aimed to describe incidence and mortality patterns of MM among children, adolescents and young adults (cAYA) in Brazil and to evaluate trends in incidence and mortality rate overtime. Methods Data were extracted from a dataset of 15 Population-based Cancer Registries located in five Brazilian geographical regions and calculated by age-specific, crude, and age-standardized incidence (ASR) and mortality rates per million persons. Joinpoint regression analyses were performed for trends evaluations, regionally. Annual Percent Change (APC) and Average Annual Percent Change (AAPC) were also estimated. Results The overall ASR for incidence and mortality of MM in Brazil was 14.57 and 8.83 per million, respectively. The AML (non-APL AML and APL) incidence rate is 8.18 per million, whereas other MM subtypes altogether have an incidence rate of 2.62 per million, and not otherwise specified (NOS) is 3.70 per million. The analysis of incidence trends (AAPC) showed a significant decline in Manaus (-5.6%) and Sao Paulo (-4.7%), and a significant increase was observed in Fortaleza (5.8%). Mortality trends steadily declined in all registries, with significant declines occurring in Goiânia (-1.5%), Belo Horizonte (-2.3%), Sao Paulo (-2.5%), Curitiba (-2.8%) and Porto Alegre (-4.1%). Conclusion Our findings showed differences in the incidence and mortality rates of MM in cAYA in Brazil, geographically. Infants-AML have the highest incidence within the cAYA population (17.42 per million). There was a substantial decrease in mortality rate observed, which was interpreted as an improvement in MM recognition and therapeutic approach. |
| Databáze: | OpenAIRE |
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