Diffusion-weighted magnetic resonance imaging for evaluation of salivary gland function in head and neck cancer patients treated with intensity-modulated radiotherapy

Autor: Mika Kapanen, Mikko Tenhunen, Venla Loimu, Laura Tuomikoski, Heidi Nurmi, Kauko Saarilahti, Antti Mäkitie, Tiina Seppälä
Přispěvatelé: University of Helsinki, Clinicum, Department of Oncology, Korva-, nenä- ja kurkkutautien klinikka, HUS Head and Neck Center, HUS Comprehensive Cancer Center
Předmět:
GUSTATORY STIMULATION
Male
ECHO-PLANAR
medicine.medical_treatment
Salivary gland scintigraphy
THERAPY
Salivary Glands
030218 nuclear medicine & medical imaging
0302 clinical medicine
Prospective Studies
Head and neck cancer
Salivary gland
medicine.diagnostic_test
PAROTID-GLAND
VALUES
INDUCED XEROSTOMIA
Radiotherapy Dosage
Hematology
Chemoradiotherapy
Middle Aged
3. Good health
Parotid gland
medicine.anatomical_structure
Oncology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Female
COEFFICIENT
MRI
Adult
3122 Cancers
03 medical and health sciences
stomatognathic system
DW-MRI
Major Salivary Gland
medicine
Humans
Radiology
Nuclear Medicine and imaging
IMRT
Aged
business.industry
Magnetic resonance imaging
medicine.disease
Ascorbic acid
Radiation therapy
Diffusion Magnetic Resonance Imaging
EXPERIENCE
SCINTIGRAPHY
Radiotherapy
Intensity-Modulated
Nuclear medicine
business
Zdroj: Tampere University
Popis: Background and purposes: Permanent xerostomia as a result of radiation-induced salivary gland damage remains a common side effect of radiotherapy (RT) of the head and neck. The purpose of this study was to evaluate the usefulness of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing the post-RT salivary gland function in patients with head and neck cancer (HNC). Materials and methods: In this prospective study, 20 HNC patients scheduled for bilateral neck chemoradiotherapy (CRT) with weekly cisplatin went through diffusion-weighted magnetic resonance imaging (DW-MRI) and salivary gland scintigraphy (SGS) prior to and at a mean of six months after completing the treatment. The changes in apparent diffusion coefficient (ADC) before and after treatment were compared with ejection fraction (EF) measured with SGS and the radiation dose absorbed by the salivary glands. Results: As a result of gustatory stimulation with ascorbic acid, the ADC showed a biphasic response with an initial increase and subsequent decrease. This pattern was seen both before and after RT. Post-RT ADC increased as a function of RT dose absorbed by the salivary glands. A moderate statistical correlation between pre- and post-RT ADCs at rest and EF measured with SGS was found. Conclusions: DW-MRI seems a promising tool for detection of physiological and functional changes in major salivary glands after RT. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Databáze: OpenAIRE
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