Does the father matter? The association between the periconceptional paternal folate status and embryonic growth
| Autor: | Sam Schoenmakers, Anton H. J. Koning, Sten P. Willemsen, Jeffrey Hoek, Régine P.M. Steegers-Theunissen, Eric A.P. Steegers, Maria P.H. Koster |
|---|---|
| Přispěvatelé: | Obstetrics & Gynecology, Epidemiology, Pathology |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Erythrocytes medicine.medical_treatment Embryonic Development Gestational Age Fertilization in Vitro Intracytoplasmic sperm injection Crown-Rump Length Ultrasonography Prenatal Fetal Development 03 medical and health sciences Fathers 0302 clinical medicine Folic Acid Imaging Three-Dimensional Pregnancy medicine Humans Prospective Studies Sperm Injections Intracytoplasmic 030219 obstetrics & reproductive medicine business.industry Obstetrics Embryogenesis Obstetrics and Gynecology Micronutrient Embryo Mammalian Confidence interval Paternal Exposure 030104 developmental biology Reproductive Medicine Quartile Gestation Female business Biomarkers Cohort study |
| Zdroj: | Journal of Urology, 202(3):446. Elsevier Inc. Fertility & Sterility, 111(2), 270-279. Elsevier Inc. |
| ISSN: | 1556-5653 0022-5347 0015-0282 |
| Popis: | Objective To study the association between periconceptional paternal folate status and embryonic growth trajectories in early pregnancy. Design Prospective periconceptional cohort study. Setting Single tertiary hospital. Patient(s) A total of 511 singleton pregnancies, with 303 conceived spontaneously and 208 after in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment. Intervention(s) None. Main Outcome Measure(s) Crown–rump length (CRL) and embryonic volume (EV) at 7, 9, and 11 weeks of gestation measured offline using three-dimensional ultrasound data and a virtual reality system. Result(s) Using the third quartile of paternal red blood cell (RBC) folate levels as reference values, we found statistically significantly negative associations between RBC folate and longitudinal CRL measurements in the second quartile (beta: −0.14 √mm [95% confidence interval (CI), −0.28 to −0.006]) and fourth quartile (beta: −0.19 √mm [95% CI, −0.33 to −0.04]) in spontaneously conceived pregnancies. Comparable results were found for longitudinal EV measurements in the fourth quartile (beta: −0.12 ∛cm3 [95% CI, −0.20 to −0.05]). No statistically significant associations were observed between RBC folate levels and embryonic growth trajectories in IVF-ICSI pregnancies. Conclusion(s) These data demonstrate for the first time that low and high periconceptional paternal RBC folate levels are associated with reduced embryonic growth trajectories in spontaneously conceived pregnancies. These data underline the importance of paternal folate status during the periconception period. |
| Databáze: | OpenAIRE |
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