Risk of malaria in young children after periconceptional iron supplementation

Autor: Stephen A Roberts, Olga M. Lompo, Sabine Gies, Halidou Tinto, Bernard J. Brabin, Salou Diallo
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Chorioamnionitis
law.invention
0302 clinical medicine
iron
Randomized controlled trial
Pregnancy
law
Medicine
030212 general & internal medicine
lcsh:RC620-627
child
Nutrition and Dietetics
Obstetrics
lcsh:RJ1-570
Obstetrics and Gynecology
Gestational age
Iron deficiency
lcsh:Nutritional diseases. Deficiency diseases
medicine.anatomical_structure
Child
Preschool
Premature Birth
Female
Original Article
medicine.medical_specialty
placenta
Offspring
malaria
wa_395
lcsh:Gynecology and obstetrics
03 medical and health sciences
Folic Acid
Placenta
Burkina Faso
parasitic diseases
Humans
periconceptional
lcsh:RG1-991
ws_430
030109 nutrition & dietetics
business.industry
Infant
Newborn
Public Health
Environmental and Occupational Health
Infant
lcsh:Pediatrics
Original Articles
medicine.disease
wc_750
ws_200
Dietary Supplements
Pediatrics
Perinatology and Child Health
Iron supplementation
business
Malaria
Zdroj: Maternal and Child Nutrition, Vol 17, Iss 2, Pp n/a-n/a (2021)
Maternal & Child Nutrition
ISSN: 1740-8709
Popis: This study in Burkina Faso investigated whether offspring of young mothers who had received weekly periconceptional iron supplementation in a randomised controlled trial were at increased risk of malaria. A child safety survey was undertaken in the peak month of malaria transmission towards the end of the trial to assess child iron biomarkers, nutritional status, anaemia and malaria outcomes. Antenatal iron biomarkers, preterm birth, fetal growth restriction and placental pathology for malaria and chorioamnionitis were assessed. Data were available for 180 babies surviving to the time of the survey when their median age was 9 months. Prevalence of maternal iron deficiency in the last trimester based on low body iron stores was 16%. Prevalence of active placental malaria infection was 24.8%, past infection 59% and chorioamnionitis 55.6%. Babies of iron supplemented women had lower median gestational age. Four out of five children ≥ 6 months were iron deficient, and 98% were anaemic. At 4 months malaria prevalence was 45%. Child iron biomarkers, anaemia and malaria outcomes did not differ by trial arm. Factors associated with childhood parasitaemia were third trimester C‐reactive protein level (OR 2.1; 95% CI 1.1–3.9), active placental malaria (OR 5.8; 1.0–32.5, P = 0.042) and child body iron stores (OR 1.13; 1.04–1.23, P = 0.002). Chorioamnionitis was associated with reduced risk of child parasitaemia (OR 0.4; 0.1–1.0, P = 0.038). Periconceptional iron supplementation of young women did not alter body iron stores of their children. Higher child body iron stores and placental malaria increased risk of childhood parasitaemia.
Databáze: OpenAIRE
Externí odkaz: