Genome-wide association study reveals two new risk loci for bipolar disorder
| Autor: | Peter R. Schofield, Sandra Meier, Stefan Herms, Paul Brennan, Susanne Moebus, Jana Strohmaier, Paul Grof, Nicholas G. Martin, Grant W. Montgomery, Adam Wright, Susanne Lucae, Maria Grigoroiu-Serbanescu, Alexey Polonikov, Peter Propping, Stephanie H. Witt, Andreas J. Forstner, Joanna Hauser, Fabio Rivas, Markus Leber, René Breuer, Piotr M. Czerski, Johannes Schumacher, Manolis Kogevinas, Neonila Szeszenia-Dabrowska, Scott D. Gordon, Sven Cichon, Jolanta Lissowska, Wolfgang Maier, Tim Becker, Alexander S. Tiganov, Thomas W. Mühleisen, Andreas Reif, Manuel Mattheisen, Michael Bauer, Galina Pantelejeva, Thomas G. Schulze, Philip B. Mitchell, Jens Treutlein, André Lacour, Marcella Rietschel, Lilia I. Abramova, Valery Krasnow, Andrea Pfennig, Martin Alda, Alexander Chuchalin, Lutz Priebe, Per Hoffmann, Janice M. Fullerton, Jutta Kammerer-Ciernioch, Markus M. Nöthen, Fermín Mayoral, Helmut Vedder, M.P. Schwarz, Gulja Babadjanova, Guy A. Rouleau, Franziska Degenhardt, Elza Khusnutdinova, Martin Hautzinger, James McKay, Bertram Müller-Myhsok, Catherine Laprise, Gustavo Turecki, Sarah E. Medland |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Bipolar Disorder Medizin General Physics and Astronomy Locus (genetics) Genome-wide association study Single-nucleotide polymorphism Disease Biology methods [Genome-Wide Association Study] Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology adenylyl cyclase 2 medicine Humans Genetic Predisposition to Disease Bipolar disorder ANK3 genetics [Genetic Predisposition to Disease] Genetic association Genetics Multidisciplinary genetics [Adenylyl Cyclases] General Chemistry medicine.disease Mental illness 3. Good health genetics [Polymorphism Single Nucleotide] Female ddc:500 genetics [Bipolar Disorder] Genome-Wide Association Study Adenylyl Cyclases |
| Zdroj: | Nature Communications 5(1), 3339 (2014). doi:10.1038/ncomms4339 Mühleisen, T W, Leber, M, Schulze, T G, Strohmaier, J, Degenhardt, F, Treutlein, J, Mattheisen, M, Forstner, A J, Schumacher, J, Breuer, R, Meier, S, Herms, S, Hoffmann, P, Lacour, A, Witt, S H, Reif, A, Müller-Myhsok, B, Lucae, S, Maier, W, Schwarz, M, Vedder, H, Kammerer-Ciernioch, J, Pfennig, A, Bauer, M, Hautzinger, M, Moebus, S, Priebe, L, Czerski, P M, Hauser, J, Lissowska, J, Szeszenia-Dabrowska, N, Brennan, P, McKay, J D, Wright, A, Mitchell, P B, Fullerton, J M, Schofield, P R, Montgomery, G W, Medland, S E, Gordon, S D, Martin, N G, Krasnow, V, Chuchalin, A, Babadjanova, G, Pantelejeva, G, Abramova, L I, Tiganov, A S, Polonikov, A, Khusnutdinova, E, Alda, M, Grof, P, Rouleau, G A, Turecki, G, Laprise, C, Rivas, F, Mayoral, F, Kogevinas, M, Grigoroiu-Serbanescu, M, Propping, P, Becker, T, Rietschel, M, Nöthen, M M & Cichon, S 2014, ' Genome-wide association study reveals two new risk loci for bipolar disorder ', Nature Communications, vol. 5, pp. 3339 . https://doi.org/10.1038/ncomms4339 Nature Communications 5, 3339 (2014). doi:10.1038/ncomms4339 |
| ISSN: | 2041-1723 |
| Popis: | Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide association studies (GWAS) have robustly identified the first common genetic variants involved in disease aetiology. The data also provide strong evidence for the presence of multiple additional risk loci, each contributing a relatively small effect to BD susceptibility. Large samples are necessary to detect these risk loci. Here we present results from the largest BD GWAS to date by investigating 2.3 million single-nucleotide polymorphisms (SNPs) in a sample of 24,025 patients and controls. We detect 56 genome-wide significant SNPs in five chromosomal regions including previously reported risk loci ANK3, ODZ4 and TRANK1, as well as the risk locus ADCY2 (5p15.31) and a region between MIR2113 and POU3F2 (6q16.1). ADCY2 is a key enzyme in cAMP signalling and our finding provides new insights into the biological mechanisms involved in the development of BD. |
| Databáze: | OpenAIRE |
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