Molecular drug susceptibility testing and genotyping of Mycobacterium leprae strains from South America

Autor: Stewart T. Cole, Carlos Rivas, Andrea de Faria Fernandes Belone, Nacarid Aranzazu, Marc Monot, Pushpendra Singh, Alberto Paniz-Mondolfi, Marcos Virmond, Nadine Honoré, Philippe Busso, Maria Esther Villarreal-Olaya
Přispěvatelé: Global Health Institute - Institut d'Infectiologie [Lausanne], Ecole Polytechnique Fédérale de Lausanne (EPFL), Instituto de Biomedicina [Caracas], Universidad Central de Venezuela (UCV), Institut Pasteur [Paris] (IP), Instituto Lauro de Souza Lima, National Leprosy Program, National Leprosy and TB Control Programme, Departamento de Laboratorio, Comisión Honoraria de Lucha Anti-Tuberculosis y Enfermedades Prevalentes, This work received the financial support of the Fondation Raoul Follereau and the National Institutes of Health, National Institute of Allergy and Infectious Diseases (grant RO1-AI47197-01A1 and contract NO1-AI25469)., Institut Pasteur [Paris]
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Male
Ofloxacin
Philippines
Drug resistance
Dapsone
medicine.disease_cause
MESH: Genotype
0302 clinical medicine
Genotype
Pharmacology (medical)
Leprosy Patients
Mycobacterium leprae
MESH: Aged
0303 health sciences
Mutation
MESH: Microbial Sensitivity Tests
MESH: Middle Aged
biology
MESH: Polymorphism
Single Nucleotide
Middle Aged
3. Good health
Infectious Diseases
Female
Leprosy
Dapsone Resistance
Rifampin
Mutations
medicine.drug
Adult
Adolescent
030231 tropical medicine
Microbial Sensitivity Tests
Polymorphism
Single Nucleotide
Microbiology
03 medical and health sciences
Drug Resistance
Bacterial
MESH: Drug Resistance
Bacterial
medicine
Humans
Genotyping
Aged
Pharmacology
MESH: Adolescent
MESH: Humans
030306 microbiology
Multibacillary Leprosy
MESH: Adult
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Molecular biology
MESH: South America
South America
medicine.disease
biology.organism_classification
Virology
MESH: Leprosy
MESH: Male
Susceptibility
MESH: Mycobacterium leprae
MESH: Female
Zdroj: Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, 2011, 55 (6), pp.2971-3. ⟨10.1128/AAC.00201-11⟩
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2011, 55 (6), pp.2971-3. ⟨10.1128/AAC.00201-11⟩
ISSN: 0066-4804
1098-6596
DOI: 10.1128/AAC.00201-11⟩
Popis: Possible drug resistance in Mycobacterium leprae strains from Venezuela and three other South American countries was surveyed by molecular methods. None of the 230 strains from new leprosy cases exhibited drug resistance-associated mutations. However, two of the three strains from relapsed cases contained dapsone resistance mutations, and one strain also harbored a rifampin resistance mutation. Single nucleotide polymorphism analysis of these strains revealed five subtypes: 3I (73.8%), 4P (11.6%), 1D (6.9%), 4N (6%), and 4O (1.7%).
Databáze: OpenAIRE
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