OBHS impairs the viability of breast cancer via decreasing ERα and Atg13
Autor: | Hai-Bing Zhou, Jiawei Zhou, Jian Huang, Rong Shen |
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Rok vydání: | 2021 |
Předmět: |
Cell Survival
Biophysics Autophagy-Related Proteins Estrogen receptor Antineoplastic Agents Breast Neoplasms Biology Biochemistry Breast cancer medicine Humans skin and connective tissue diseases Molecular Biology Transcription factor Cells Cultured Cell Proliferation Autophagy Estrogen Receptor alpha Cancer Cell Biology Autophagy-related protein 13 Bridged Bicyclo Compounds Heterocyclic medicine.disease HEK293 Cells Selective estrogen receptor modulator Cancer research Drug Screening Assays Antitumor Sulfonic Acids Estrogen receptor alpha |
Zdroj: | Biochemical and Biophysical Research Communications. 573:69-75 |
ISSN: | 0006-291X |
Popis: | Breast cancer (BRCA) is one of the most threatening cancer types, especially among the female population. 70% of breast cancer are estrogen receptor α (ERα) positive and endocrine therapy is effective to decrease breast cancer risk. Autophagy, a highly conserved cellular recycling process, has been regarded to serve a protective role in BRCA. Autophagy-related gene 13 (Atg13) is participated in autophagy and is critical to autophagy initiation. Briefly, we observed that ERα, a well-known transcription factor that can promote breast cancer cell proliferation, expressed higher in breast cancer tissues. Moreover, ERα had a significant positive correlation with Atg13 and may be able to regulate the transcription of Atg13 via binding the promoter region of Atg13. Surprisingly, Oxabicycloheptene sulfonate (OBHS), the drug that we reported as a selective estrogen receptor modulator (SERM) before, may have the ability to decrease the expression of ERα and suppress the autophagy. In conclusion. We found that ERα could be involved in autophagy by binding the promoter of Atg13, and compound OBHS may be able to affect the viability of breast cancer cells by decreasing the expression of ERα and Atg13. |
Databáze: | OpenAIRE |
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