Neutrophils in cancer: heterogeneous and multifaceted
| Autor: | Catherine C. Hedrick, Ilaria Malanchi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
History
Human blood Neutrophils business.industry Cancer Cell Differentiation Context (language use) Disease Biology medicine.disease Computer Science Applications Education Functional diversity Functional importance Tumour development Neoplasms Tumor Microenvironment medicine Humans Myeloid Cells business Neuroscience Biomedicine |
| Zdroj: | Nature Reviews Immunology. 22:173-187 |
| ISSN: | 1474-1741 1474-1733 |
| DOI: | 10.1038/s41577-021-00571-6 |
| Popis: | Neutrophils are the most abundant myeloid cells in human blood and are emerging as important regulators of cancer. However, their functional importance has often been overlooked on the basis that they are short-lived, terminally differentiated and non-proliferative. Recent studies of their prominent roles in cancer have led to a paradigm shift in our appreciation of neutrophil functional diversity. This Review describes how neutrophil diversification, which in some contexts can lead to opposing functions, is generated within the tumour microenvironment as well as systemically. We compare neutrophil heterogeneity in cancer and in other pathophysiological contexts to provide an updated overview of our current knowledge of the functions of neutrophils in cancer. Neutrophils are much more than just primary responders in infection. They influence tumour development and growth in many positive and negative ways. A growing appreciation of their diversity and plasticity is revealing their complex contributions to cancer depending on time, place and disease context. |
| Databáze: | OpenAIRE |
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