Functionalized Porous Silica Microspheres as Scavengers in Parallel Synthesis
| Autor: | J J Kirkland, Q Wangb, G L Trainor, L A Thompsona, T J Langloisb, A P Combsa |
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| Rok vydání: | 2000 |
| Předmět: |
Materials science
Molecular Structure Organic Chemistry New materials Nanotechnology General Medicine Silicon Dioxide Amides Microspheres Computer Science Applications Microsphere chemistry.chemical_compound chemistry Reagent Drug Discovery Solvents Combinatorial Chemistry Techniques Molecule Organic synthesis Polystyrene Porosity |
| Zdroj: | Combinatorial Chemistry & High Throughput Screening. 3:107-115 |
| ISSN: | 1386-2073 |
| DOI: | 10.2174/1386207003331670 |
| Popis: | The use of solid scavengers in parallel solution-phase organic synthesis is an effective method for work-up and purification. Functionalized macroreticular or gel-form polystyrene particles are generally used for scavenging applications, how ever these materials have some limitations. We have developed new scavenging reagents based on ultrapure silica microspheres displaying a variety of functional groups useful for sequestering impurities from reaction products. These materials are easy to handle, have excellent mass-transfer properties, and are efficient scavengers in both polar and nonpolar organic solvents. The properties of these materials were tailored specifically to fit the needs of a medicinal chemist employing parallel synthesis techniques in current commercial equipment. Results are presented from head-to-head comparisons with conventional scavengers in tests designed to demonstrate the versatility of these new materials. |
| Databáze: | OpenAIRE |
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