Subchronic Systemic Toxicity and Bioaccumulation of Fe3O4 Nano- and Microparticles Following Repeated Intraperitoneal Administration to Rats
| Autor: | Olga S. Yeremenko, V. A. Vazhenin, Ekaterina P. Kireyeva, Maria V. Morozova, Marina P. Sutunkova, Irene I. Valamina, Alisa Nikolaevna Kozitsina, Larisa I. Privalova, Boris A. Katsnelson, Tamara D. Degtyareva, Sergey V. Kuzmin, Mark Y. Khodos, A. P. Potapov, Ilzira I. Minigalieva, Vladimir Ya. Shur |
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| Rok vydání: | 2011 |
| Předmět: |
Iron
Metal Nanoparticles Spleen Toxicology Toxicity Tests medicine Animals Toxicokinetics Particle Size Solubility Aqueous solution Chemistry Spectrophotometry Atomic Electron Spin Resonance Spectroscopy Penetration (firestop) Ferrosoferric Oxide Rats medicine.anatomical_structure Liver Bioaccumulation Toxicity Female Particle size Injections Intraperitoneal Nuclear chemistry |
| Zdroj: | International Journal of Toxicology. 30:59-68 |
| ISSN: | 1092-874X 1091-5818 |
| DOI: | 10.1177/1091581810385149 |
| Popis: | Aqueous suspensions of 10 nm, 50 nm, or 1 μm Fe3O4 particles were injected intraperitoneally (ip) to rats at a dose of 500 mg/kg in 4 mL of sterile deionized water 3 times a week for 5 weeks. Following exposure, functional and biochemical indices and histopathological examinations of spleen and liver tissues of exposed rats were evaluated for signs of toxicity. The iron content of the blood was measured photometrically, and that of the liver and the spleen by atomic adsorption spectroscopy (AAS) and electron paramagnetic resonance (EPR) methods. It was found that, given equal mass doses, Fe3O4 nanoparticles possess considerably higher systemic toxicity than microparticles, but within the nanometric range the relationship between particle size and resorptive toxicity is intricate and nonunique. The latter fact may be attributed to differences in different nanoparticles' toxicokinetics, which are controlled by both more or less substantial direct penetration of nanoparticles through biological barriers and their unequal solubility. |
| Databáze: | OpenAIRE |
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