Sensitive Voltammetric Detection of Chloroquine Drug by Applying a Boron-Doped Diamond Electrode
| Autor: | Paulo Roberto de Oliveira, Déborah Christine Azzi, Geiser Gabriel Oliveira, Tiago Almeida Silva, Bruno C. Janegitz, Orlando Fatibello-Filho |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
boron-doped diamond
Materials science Inorganic chemistry 02 engineering and technology engineering.material Electrochemistry 01 natural sciences Cathodic protection lcsh:QD241-441 chloroquine lcsh:Organic chemistry square-wave voltammetry electroanalysis Voltammetry Boron doped diamond Detection limit pharmaceutics 010401 analytical chemistry Diamond General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences Anode Electrode engineering 0210 nano-technology |
| Zdroj: | Volume 6 Issue 4 C, Vol 6, Iss 75, p 75 (2020) |
| ISSN: | 2311-5629 |
| DOI: | 10.3390/c6040075 |
| Popis: | In this research, a boron-doped diamond (BDD) electrode has been explored to detect the chloroquine drug. The electrochemical performance of BDD electrode towards the irreversible anodic response of chloroquine was investigated by subjecting this electrode to the cathodic (&minus 0.5 A cm&minus 2 by 180 s, generating a predominantly hydrogen-terminated surface) and anodic (+0.5 A cm&minus 2 by 30 s, oxygen-terminated surface) pretreatments. The cathodically pretreated BDD electrode ensured a better-defined anodic peak and higher current intensity. Thus, by applying the cathodically pretreated BDD electrode and square-wave voltammetry (SWV), the analytical curve was linear from 0.01 to 0.25 µ mol L&minus 1 (correlation coefficient of 0.994), with sensitivity and limit of detection of 12.2 µ A L µ mol&minus 1 and 2.0 nmol&minus 1, respectively. This nanomolar limit of detection is the lowest recorded so far with modified and unmodified electrodes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|