Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform
| Autor: | Andrew Z. Wang, Liangfang Zhang, Aleksandar Filip Radovic-Moreno, Frank Alexis, Robert Langer, Juliana M. Chan, Omid C. Farokhzad, Frank X. Gu, June-Wha Rhee |
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| Rok vydání: | 2009 |
| Předmět: |
Drug
Materials science Macromolecular Substances Polymers Surface Properties media_common.quotation_subject Molecular Conformation General Physics and Astronomy Nanoparticle Nanotechnology Systemic circulation Article Self assembled Diffusion Materials Testing General Materials Science Particle Size media_common chemistry.chemical_classification Liposome Drug Carriers General Engineering Polymer Lipids Nanostructures Nanomedicine chemistry Pharmaceutical Preparations Solubility Drug Design Drug delivery Self-assembly Crystallization Hydrophobic and Hydrophilic Interactions |
| Zdroj: | ACS nano. 2(8) |
| ISSN: | 1936-086X |
| Popis: | We report the engineering of a novel lipid-polymer hybrid nanoparticle (NP) as a robust drug delivery platform, with high drug encapsulation yield, tunable and sustained drug release profile, excellent serum stability, and potential for differential targeting of cells or tissues. The NP is comprised of three distinct functional components: i) a hydrophobic polymeric core where poorly water-soluble drugs can be encapsulated; ii) a hydrophilic polymeric shell with anti-biofouling properties to enhance NP stability and systemic circulation half-life; and iii) a lipid monolayer at the interface of the core and the shell that acts as a molecular fence to promote drug retention inside the polymeric core, thereby enhancing drug encapsulation efficiency, increasing drug loading yield, and controlling drug release. The NP is prepared by self-assembly through a single-step nanoprecipitation method in a reproducible and predictable manner, making it potentially suitable for scale-up |
| Databáze: | OpenAIRE |
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