Effect of length of gestation on maternal cellular immunity to human trophoblast antigens
| Autor: | J.S. Scott, K. W. Hancock, G. Gowland, Pamela V. Taylor |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
medicine.medical_specialty
Cellular immunity Placenta Lymphocyte Gestational Age Biology Antigen Pregnancy Internal medicine medicine Humans Lymphocytes Antigens Maternal-Fetal Exchange Incubation Antilymphocyte Serum Immunity Cellular Fetus Obstetrics and Gynecology Trophoblast Cytotoxicity Tests Immunologic medicine.disease Trophoblasts medicine.anatomical_structure Endocrinology embryonic structures Gestation Female |
| Zdroj: | American Journal of Obstetrics and Gynecology. 125:528-531 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/0002-9378(76)90371-9 |
| Popis: | Maternal lymphocyte reactivity to human trophoblast antigens was studied in placentas of gestational ages 8 to 14 weeks and 32 to 34 weeks, respectively. Significant trophoblast lysis became apparent after 24 hours' incubation in the latter case compared with a time lag of 72 hours in the terminated gestations. Maternal cellular immunity, therefore, was not detected during the first 3½ months of pregnancy, but was detectable by the time of parturition. The possible significance is discussed with respect to the antigenic stimulus and survival of the fetal allograft. |
| Databáze: | OpenAIRE |
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