Cervical Coinfection with Human Papillomavirus (HPV) Types and Possible Implications for the Prevention of Cervical Cancer by HPV Vaccines
| Autor: | Fabian, Mendez, Nubia, Munoz, Hector, Posso, Monica, Molano, Victor, Moreno, Adrian J C, van den Brule, Margarita, Ronderos, Chris, Meijer, Alvaro, Munoz |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Adolescent Uterine Cervical Neoplasms HPV vaccines Colombia Papillomavirus Vaccines Species Specificity Risk Factors Odds Ratio medicine Humans Immunology and Allergy Sex organ Papillomaviridae Aged Aged 80 and over Cervical cancer business.industry Incidence Incidence (epidemiology) Papillomavirus Infections HPV infection virus diseases Viral Vaccines Odds ratio Middle Aged medicine.disease female genital diseases and pregnancy complications Infectious Diseases Immunology Coinfection Female business |
| Zdroj: | The Journal of Infectious Diseases. 192:1158-1165 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/444391 |
| Popis: | Coinfection with multiple types of human papillomavirus (HPV) and its implications for the development of efficacious HPV vaccines is a subject of great interest. To describe the occurrence of concurrent infection with multiple HPV types and to determine whether genital HPV infection modifies the risk of acquiring a new HPV infection with another HPV type, 1610 subjects were monitored for an average of 4.1 years in Bogota, Colombia. Information on risk factors for HPV infection and cervical cells was collected for detection of HPV DNA of 36 types at study entry and at 6 consecutive 6-month follow-up visits. Clustering or the concurrent acquisition of multiple types occurred more often than would be expected by chance. Subjects with incident HPV-16 or -18 infection had 5-7 times higher odds of acquiring a subsequent HPV-58 infection than subjects not infected with HPV-16 or -18. This might affect the protection conferred by effective HPV vaccines. |
| Databáze: | OpenAIRE |
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