Effects of combined dietary supplementation on oxidative and inflammatory status in dyslipidemic subjects
| Autor: | E. Lorenzano, M. Gorini, C. Della Noce, F. Bernacchi, Cristina Novembrino, S. Lonati, S. Ippolito, S. Grossi, M. Rosina, L. Ghersi, R. Accinni, R. Caruso, Fabrizia Bamonti, A. Tonini, Jonica Campolo, A. Ciani |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Thromboxane Endocrinology Diabetes and Metabolism medicine.medical_treatment Medicine (miscellaneous) Hyperlipidemias Placebo medicine.disease_cause Niacin Antioxidants Risk Factors Internal medicine Fatty Acids Omega-3 medicine Humans Vitamin E Aged Hypolipidemic Agents Nutrition and Dietetics medicine.diagnostic_test Phenylpropionates business.industry Interleukin Middle Aged medicine.disease Atherosclerosis Lipid Metabolism Oxidative Stress Endocrinology Dietary Supplements Cytokines Drug Therapy Combination Female Inflammation Mediators Cardiology and Cardiovascular Medicine Lipid profile business Reactive Oxygen Species Oxidation-Reduction Dyslipidemia Oxidative stress |
| Zdroj: | Nutrition, metabolism, and cardiovascular diseases : NMCD. 16(2) |
| ISSN: | 0939-4753 |
| Popis: | Background and aim Dyslipidemia is one of the main risk factors for atherosclerosis, usually the underlying cause of cardiovascular diseases which are the major cause of morbidity and mortality in developed countries. The aim of this study was to assess the effects and the advantages of a combined dietary supplementation with PUFA n-3, vitamin E, niacin and γ-oryzanol on lipid profile, inflammatory status and oxidative balance. Methods and results Fifty-seven dyslipidemic volunteers were randomly assigned to receive: placebo (group A, 19 subjects); PUFA n-3 and vitamin E (group B, 18 subjects); the same as B plus γ-oryzanol and niacin (group C, 20 subjects). Lipid profile, reactive oxygen species (ROS), total antioxidant capacity (TAC), vitamin E, interleukin 1-β (IL1-β), tumor necrosis factor (TNF-α) and thromboxane B 2 (TXB 2 ) were determined at baseline (T0) and after four months (T1). All dyslipidemic subjects showed, at baseline, oxidative stress and, after four months, all biochemical markers improved significantly in groups treated with dietary supplementation. Particularly in group C all lipid patterns improved significantly. Conclusions Our findings demonstrate that the strategy of combining different compounds, which protect each other and act together at different levels of the lipid chain production, improves lipid profile, inflammatory and oxidative status, allowing us to reduce the dose of each compound under the threshold of its side effects. |
| Databáze: | OpenAIRE |
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