Development and characterization of a scalable microperforated device capable of long-term zero order drug release
| Autor: | Zhiquan Luo, Phillip D. Bowman, Zhuojie Wu, Paul S. Ho, Salomon A Stavchansky, Ashish Rastogi |
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| Rok vydání: | 2010 |
| Předmět: |
Zero order
Materials science Chromatography Phosphate buffered saline Biomedical Engineering Ethinyl Estradiol Imides In vitro analysis chemistry.chemical_compound Drug Delivery Systems chemistry Drug delivery Drug release Animals Microtechnology Gentian Violet Rabbits Crystal violet Molecular Biology Polyimide Ex vivo Biomedical engineering |
| Zdroj: | Biomedical Microdevices. 12:915-921 |
| ISSN: | 1572-8781 1387-2176 |
| DOI: | 10.1007/s10544-010-9446-x |
| Popis: | A drug delivery system that consists of microperforated polyimide microtubes was developed and characterized. Two groups of polyimide tubes were used. One set consisted of microtubes (I.D. = 125 microm) with 32.9 +/- 1.7 microm size holes. The second set consisted of larger tubes (I.D. = 1000 microm) with 362-542 microm holes. The number of holes was varied between 1 and 3. The small tubes were loaded with crystal violet (CV) and ethinyl estradiol (EE) and the drug release studies were performed in 0.01 M phosphate buffered saline (PBS) (pH 7.1-7.4) at 37.0 +/- 1.0 degrees C for upto 4 weeks. The large tubes were loaded with CV and the drug release was studied in vitro in PBS and also ex vivo in rabbit's vitreous humor. Linear release rates with R(2)0.9900 were obtained for all groups with CV and EE. Release rates of 7.8 +/- 2.5, 16.2 +/- 5.5, and 22.5 +/- 6.0 ng/day for CV and 30.1 +/- 5.8 ng/day for EE were obtained for small tubes. For large tubes, a release rate of 10.8 +/- 4.1, 15.8 +/- 4.8 and 22.1 +/- 6.7 microg/day was observed in vitro in PBS and a release rate of 5.8 +/- 1.8 microg/day was observed ex vivo in vitreous humor. |
| Databáze: | OpenAIRE |
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