Decreased basal despite enhanced agonist-stimulated effects of nitric oxide in 12-week-old stroke-prone spontaneously hypertensive rat
| Autor: | Fiona J. Dowell, Anna F. Dominiczak, William Martin, Carlene A. Hamilton |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Aorta Thoracic Vasodilation Nitric Oxide Rats Inbred WKY Nitric oxide Nitroglycerin Phenylephrine Basal (phylogenetics) chemistry.chemical_compound Spontaneously hypertensive rat Species Specificity Rats Inbred SHR medicine.artery Internal medicine medicine Animals Vasoconstrictor Agents Enzyme Inhibitors Pharmacology Aorta Dose-Response Relationship Drug business.industry Anatomy Acetylcholine Rats Carotid Arteries NG-Nitroarginine Methyl Ester Endocrinology medicine.anatomical_structure chemistry Vasoconstriction Female Endothelium Vascular business medicine.drug Blood vessel |
| Zdroj: | European Journal of Pharmacology. 379:175-182 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/s0014-2999(99)00511-7 |
| Popis: | This study examined both basal and agonist-stimulated effects of nitric oxide in rings of thoracic aorta and carotid artery from 12-week-old stroke-prone spontaneously hypertensive rats (SHRSP) and compared them to those found in rings from normotensive Wistar Kyoto (WKY) controls. Acetylcholine-induced endothelium-dependent relaxation was found to be five-fold more sensitive in both male and female SHRSP when compared with those from age- and sex-matched WKY rats. In contrast, we found a reduction in the effects of basal nitric oxide in the SHRSP rat. Specifically, the ability of basal nitric oxide to depress contractile responses to phenylephrine was found to be reduced in vessels from SHRSP when compared with those from WKY rats. In addition, the endothelium-dependent depression of vasodilator responses to the nitric oxide donor, glyceryl trinitrate, was reduced in vessels from SHRSP when compared to those from WKY rats. Thus, we have shown that the effects of basal nitric oxide are impaired in the SHRSP rat at an age when the effects of agonist-stimulated nitric oxide are actually enhanced. This impairment may be related to the greater susceptibility of basal nitric oxide to destruction by superoxide anion which is known to be produced in excess in this model of hypertension. |
| Databáze: | OpenAIRE |
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