Incidence of dementia after age 90 in a multiracial cohort
| Autor: | Charles P. Quesenberry, Rachel A. Whitmer, Elizabeth Rose Mayeda, Maria M. Corrada, M. Maria Glymour, Paola Gilsanz, Catherine Lee, Claudia H. Kawas |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Epidemiology Ethnic group Competing risks Article Cohort Studies 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Developmental Neuroscience mental disorders Ethnicity Humans Medicine Dementia 030212 general & internal medicine Aged 80 and over business.industry Proportional hazards model Incidence Health Policy Medical record Incidence (epidemiology) medicine.disease Psychiatry and Mental health Cohort Female Neurology (clinical) Geriatrics and Gerontology business 030217 neurology & neurosurgery Demography |
| Zdroj: | Alzheimer's & Dementia. 15:497-505 |
| ISSN: | 1552-5279 1552-5260 |
| Popis: | Introduction Little is known about dementia incidence in diverse populations of oldest-old, the age group with highest dementia incidence. Methods Incident dementia diagnoses from 1/1/2010 to 9/30/2015 were abstracted from medical records for 2350 members of an integrated health care system in California (n = 1702 whites, n = 375 blacks, n = 105 Latinos, n = 168 Asians) aged ≥90 in 2010. We estimated race/ethnicity-specific age-adjusted dementia incidence rates and implemented Cox proportional hazards models and Fine and Gray competing risk of death models adjusted for demographics and comorbidities in midlife and late-life. Results Dementia incidence rates (n = 771 cases) were lowest among Asians (89.9/1000 person-years), followed by whites (96.9/1000 person-years), Latinos (105.8/1000 person-years), and blacks (121.5/1000 person-years). Cox regression and competing risk models estimated 28% and 36% higher dementia risk for blacks versus whites adjusting for demographics and comorbidities. Discussion Patterns of racial/ethnic disparities in dementia seen in younger older adults continue after the age of 90 years, though smaller in magnitude. |
| Databáze: | OpenAIRE |
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