Exposure to low doses of Coxiella burnetii caused high illness attack rates : Insights from combining human challenge and outbreak data
| Autor: | Nico T. Mutters, Peter Teunis, Russell John Brooke, Olivier Péter, Mirjam Kretzschmar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Epidemiology Q fever Biology Research Support Microbiology lcsh:Infectious and parasitic diseases Disease Outbreaks Young Adult Sex Factors Virology Dose response medicine Journal Article Humans lcsh:RC109-216 Young adult Child Non-U.S. Gov't Q-fever Infectivity Incidence Research Support Non-U.S. Gov't Exposure estimates Low dose Age Factors Public Health Environmental and Occupational Health Infant Outbreak Middle Aged Pathogenicity medicine.disease Coxiella burnetii biology.organism_classification Infectious Diseases Child Preschool Immunology Female Parasitology Q Fever Switzerland |
| Zdroj: | Epidemics, 11, 1. Elsevier Epidemics, Vol 11, Iss C, Pp 1-6 (2015) |
| ISSN: | 1755-4365 |
| Popis: | a b s t r a c t Background: As a major zoonotic pathogen, characterization of the infectivity and pathogenicity of Coxiella burnetii is essential to understand Q-fever epidemiology. Objectives: We want to extend a recently published human dose response model based on experimental challenge of young adult males to include other age groups and both genders. Additionally, we can estimate the spatial distribution of exposure based on observed outbreak data. Methods: Dose response assessment based on human challenge, is extended by including outbreak data, using location of cases as a proxy for exposure. This allows estimation of the influence of age and gender on the probability of developing symptoms of acute respiratory illness. Results: In an outbreak in Switzerland, in 1983, exposure to C. burnetii was shown to depend strongly on distance from the source. The susceptibility of males to develop Q-fever decreases with age, while in females, middle-aged women appear to have the lowest risk. Conclusions: The published dose response model for Q-fever, based on experimental challenge of a small group of human volunteers, has been updated with data from a well studied outbreak. Infectivity esti- mates remain high, and even low doses (of 10 or fewer organisms) cause a high risk of illness. © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Databáze: | OpenAIRE |
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