Incidences and range of spontaneous findings in control cynomolgus monkeys (Macaca fascicularis) used in toxicity studies
| Autor: | Ana I. Blanco, Alys Bradley, Stuart W. Naylor, Ronnie Chamanza, Heike A. Marxfeld |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pathology medicine.medical_specialty Accessory spleen Biology Toxicology Pathology and Forensic Medicine Animals Laboratory Toxicity Tests medicine Animals Molecular Biology Retrospective Studies Myocardial Degeneration Ectopic thymus Histocytochemistry Stomach Incidence (epidemiology) Thyroid Monkey Diseases Cell Biology medicine.disease Macaca fascicularis medicine.anatomical_structure Toxicity Female Pancreas |
| Zdroj: | Toxicologic pathology. 38(4) |
| ISSN: | 1533-1601 |
| Popis: | The authors performed a retrospective study to determine the incidences and range of spontaneous pathology findings in control cynomolgus monkeys. Data were collected from 570 monkeys (285 animals per sex), aged twelve to thirty-six months, from sixty regulatory studies evaluated at our laboratory between 2003 and 2009. The most common finding overall was lymphoplasmacytic infiltrates observed in the following incidence: liver (60.7%), kidneys (28.8%), heart (25.8%), salivary glands (21.2%), and stomach (12.1%). Inflammation also commonly occurred in the heart, kidneys, lungs, and stomach. The most common degenerative changes were localized fatty change in the liver, myocardial degeneration, and mineralization and pigment deposits in various tissues. Parathyroid, thyroid, and pituitary cysts; ectopic thymus in the parathyroid or thyroid gland; accessory spleen within the pancreas; and adrenohepatic fusion were among the most common congenital findings. Some incidental findings bearing similarities to drug-induced lesions were also encountered in various organs. It is hoped that the results presented here and elsewhere could form the groundwork for the creation of a reliable database of incidental pathology findings in laboratory nonhuman primates. |
| Databáze: | OpenAIRE |
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