In vivo Real-Time Mass Spectrometry for Guided Surgery Application
| Autor: | Isabelle Fournier, Denis Vinatier, Eric Leblanc, Michael Ziskind, Benoit Fatou, Philippe Saudemont, Violette Mesdag, Cristian Focsa, Maxence Wisztorski, Michel Salzet |
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| Přispěvatelé: | Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 (PhLAM), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université de Lille-UNICANCER, Hôpital Jeanne de Flandres, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université Lille Nord de France (COMUE)-UNICANCER, SALZET, Michel |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Spectrum analyzer [SDV]Life Sciences [q-bio] medicine.medical_treatment Human skin Mass spectrometry 01 natural sciences Article Mass Spectrometry 03 medical and health sciences Laser therapy In vivo medicine Humans Minimally Invasive Surgical Procedures Skin pathology Skin Multidisciplinary Chemistry 010401 analytical chemistry Ablation 0104 chemical sciences 3. Good health Surgery [SDV] Life Sciences [q-bio] 030104 developmental biology Female Laser Therapy |
| Zdroj: | Scientific Reports Scientific Reports, 2016, 6, pp.25919. ⟨10.1038/srep25919⟩ Scientific Reports, Nature Publishing Group, 2016, 6, pp.25919. ⟨10.1038/srep25919⟩ |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep25919 |
| Popis: | Here we describe a new instrument (SpiderMass) designed for in vivo and real-time analysis. In this instrument ion production is performed remotely from the MS instrument and the generated ions are transported in real-time to the MS analyzer. Ion production is promoted by Resonant Infrared Laser Ablation (RIR-LA) based on the highly effective excitation of O-H bonds in water molecules naturally present in most biological samples. The retrieved molecular patterns are specific to the cell phenotypes and benign versus cancer regions of patient biopsies can be easily differentiated. We also demonstrate by analysis of human skin that SpiderMass can be used under in vivo conditions with minimal damage and pain. Furthermore SpiderMass can also be used for real-time drug metabolism and pharmacokinetic (DMPK) analysis or food safety topics. SpiderMass is thus the first MS based system designed for in vivo real-time analysis under minimally invasive conditions. |
| Databáze: | OpenAIRE |
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