Comparison of Human Papilloma Virus Testing and Spectroscopy Combined With Cervical Cytology for the Detection of High-grade Cervical Neoplasia
| Autor: | William F. Griffith, David Mongin, Claudia L. Werner, Edward J. Wilkinson, Diana Gossett, Mark L. Faupel, Shabbir Bambot, Stephen S. Raab, Raheela Ashfaq |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Biopsy Population Uterine Cervical Neoplasms Cervix Uteri Endocervical curettage Cervical intraepithelial neoplasia Sensitivity and Specificity Gastroenterology Dilatation and Curettage Double-Blind Method Predictive Value of Tests Internal medicine Cytology medicine Humans Neoplasm Invasiveness Prospective Studies education Papillomaviridae Cervix Vaginal Smears Colposcopy education.field_of_study medicine.diagnostic_test business.industry Obstetrics and Gynecology General Medicine Middle Aged Uterine Cervical Dysplasia medicine.disease female genital diseases and pregnancy complications Koilocyte Spectrometry Fluorescence medicine.anatomical_structure DNA Viral Female business |
| Zdroj: | Journal of Lower Genital Tract Disease. 11:73-79 |
| ISSN: | 1089-2591 |
| Popis: | Objective. This study compared the performance of cervical cytology plus human papilloma virus testing (Pap + HPV) or cervical spectroscopy (Pap + CS) for identifying high-grade cervical neoplasia in a high-risk population of women referred for colposcopy. Materials and Methods. Each of 113 subjects underwent spectroscopy, thin-layer cytology, HPV testing, colposcopy, biopsy when indicated, and/or endocervical curettage. Evaluable data for analysis were collected for 102 of the subjects. Sensitivity and specificity were calculated for both strategies. Results. Pap + HPV and Pap + CS achieved equivalent sensitivities (95%) for high-grade lesions, with both detecting 17 of 18 histology confirmed cervical intraepithelial neoplasia (CIN) 2+ lesions. Pap + HPV had a specificity of only 27.4% compared with 65.5% for Pap + CS (p Conclusions. Spectroscopic interrogation of the cervix is equally sensitive and 2-fold more specific than HPV testing when combined with cervical cytology for identifying high-grade cervical neoplasia. |
| Databáze: | OpenAIRE |
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