Insulin sensitivity in normocalcaemic primary hyperparathyroidism
| Autor: | M. Maccario, F. Tassone, Giampaolo Magro, S. Cassibba, F. Cesario, Laura Gianotti, Claudia Baffoni, Micaela Pellegrino, Giorgio Borretta |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Hypercalcaemia endocrine system diseases Endocrinology Diabetes and Metabolism Gastroenterology Endocrinology Insulin resistance Internal medicine Diabetes mellitus Healthy volunteers medicine Humans Insulin Aged business.industry Insulin sensitivity Large series Middle Aged Hyperparathyroidism Primary medicine.disease Case-Control Studies Female Insulin Resistance business Primary hyperparathyroidism |
| Zdroj: | Endocrine. 44:812-814 |
| ISSN: | 1559-0100 1355-008X |
| DOI: | 10.1007/s12020-013-0059-z |
| Popis: | An altered glucose tolerance and an increased prevalence of diabetes mellitus in primary hyperparathyroidism have been reported due to an increased insulin resistance in these patients [1]. Furthermore, a significant relationship between hypercalcaemia and insulin sensitivity has been reported [2]. ‘‘Normocalcaemic’’ primary hyperparathyroidism (NCpHPT), recently recognized by some authors as a peculiar early presentation of symptomatic pHPT, is not well clinically characterized, as the few data in literature are questionable since its rigorous classification following all the strict diagnostic criteria often was not performed [3]. In particular, at our knowledge, only one case–control study recently reported a non-significantly different insulin sensitivity and glucose tolerance in these patients compared to healthy volunteers [4]. Thus, in our large series of pHPT patients we sought to investigate glucose tolerance, estimates of insulin sensitivity and secretion in the subset of patients rigorously classified as NCpHPT. Patients and methods |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink