Latent Infection with Cytomegalovirus Is Associated with Poor Memory CD4 Responses to Influenza A Core Proteins in the Elderly
| Autor: | Karin Hähnel, Graham Pawelec, Janet E. McElhaney, Andrea B. Maier, Evelyna Derhovanessian, Eline Slagboom |
|---|---|
| Přispěvatelé: | Internal medicine, MOVE Research Institute |
| Rok vydání: | 2014 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Aging T cell Immunology Cytomegalovirus CD8-Positive T-Lymphocytes Biology medicine.disease_cause Virus Cohort Studies Influenza A virus medicine Humans Immunology and Allergy Cytotoxic T cell Aged Aged 80 and over Viral Core Proteins virus diseases Immunosenescence Middle Aged Virology Virus Latency Vaccination medicine.anatomical_structure Influenza Vaccines Cytomegalovirus Infections Female Immunologic Memory Memory T cell CD8 |
| Zdroj: | Journal of Immunology, 193(7), 3624-3631. American Association of Immunologists Journal of Immunology, 193(7), 3624-3631 Derhovanessian, E, Maier, A B, Hahnel, K, McElhaney, J E, Slagboom, E P & Pawelec, G 2014, ' Latent Infection with Cytomegalovirus Is Associated with Poor Memory CD4 Responses to Influenza A Core Proteins in the Elderly ', Journal of Immunology, vol. 193, no. 7, pp. 3624-3631 . https://doi.org/10.4049/jimmunol.1303361 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.1303361 |
| Popis: | Influenza remains a major pathogen in older people. Infection with CMV and the accumulation of late-differentiated T cells associated with it have been implicated in poor Ab responsiveness to influenza vaccination in the elderly, most of whom are CMV positive. However, whether CMV infection also affects memory T cell responses to influenza remains unknown. To investigate this, we assessed T cell responses to influenza A matrix protein and nucleoprotein ex vivo in 166 Dutch individuals (mean age 62.2 y, range 42–82) and validated the results in a second cohort from North America (mean age 73.1 y, range 65–81, n = 28). We found that less than half of the CMV-infected older subjects mounted a CD4 T cell response to influenza Ags, whereas ∼80% of uninfected elderly did so. A similar proportion of younger subjects possessed influenza A virus–responsive CD4 T cells, and, interestingly, this was the case whether they were CMV-infected. Thus, the effect of CMV was only seen in the older donors, who may have been exposed to the virus for decades. The percentage of donors with CD8 responses to influenza A virus was lower than those with CD4; this was not influenced by whether the subjects were CMV seropositive or seronegative. CMV-seropositive responders had significantly higher frequencies of late-differentiated CD4 T-cells (CD45RA+/−CCR7−CD27−CD28−) compared with CMV-infected nonresponders. These data add to the accumulating evidence that infection with CMV has profound but heterogeneous effects on responses to the products of other viruses and have implications for the design of influenza vaccines, especially in the elderly. |
| Databáze: | OpenAIRE |
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