Does Cardiopulmonary Bypass Alter Plasma Level of Tumor Markers? CA 125 and Carcinoembryonic Antigen
| Autor: | F. Kosar, Emin Kaya, Nevzat Erdil, B. Yıldırım, Vedat Nisanoglu, B. Ozgur, H. Karagoz, Bektas Battaloglu |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Bypass grafting Inflammatory response Coronary Disease Gastroenterology law.invention Coronary artery bypass surgery Carcinoembryonic antigen law Internal medicine medicine Cardiopulmonary bypass Humans In patient Coronary Artery Bypass Aged Cardiopulmonary Bypass biology business.industry Plasma levels Middle Aged Carcinoembryonic Antigen surgical procedures operative medicine.anatomical_structure CA-125 Antigen Immunology biology.protein Female Surgery Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | The Thoracic and Cardiovascular Surgeon. 50:201-203 |
| ISSN: | 1439-1902 0171-6425 |
| Popis: | Background In addition to malignant diseases, acute and chronic inflammations may elevate plasma levels of tumor markers CA 125 and carcinoembryonic antigen (CEA). Cardiopulmonary bypass (CPB) causes a generalized inflammatory response. In this study, we have investigated the effect of CPB on plasma levels of CA 125 and CEA. Methods We measured plasma levels of CA 125 and CEA in patients undergoing coronary artery bypass grafting (CABG) with CPB (Group 1, n = 21), and in patients who underwent off-pump CABG, that is, without CPB (Group 2, n = 16). Blood samples were collected preoperatively, and on postoperative days 1, 6, and 12. Results Within both groups, CEA plasma levels were not significantly influenced in any samples. Comparing with preoperative values, CA 125 values elevated significantly on postoperative days 6 and 12 within both groups. It was observed that the elevation of CA 125 plasma levels in these samples were significantly higher in Group 1. Conclusions The results indicate that CPB elevated plasma level of CA 125. However, clinical importance of this finding needed further evaluation. |
| Databáze: | OpenAIRE |
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