Prophylactic analgesia before percutaneous liver biopsy
| Autor: | Yaacov Baruch, Elon Eisenberg, Rimma Kramskay, Alex Tansky, Ella Veitsman |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Visual analogue scale Analgesic Pain Anxiety Lorazepam Biopsy medicine Humans Tramadol Pain Measurement Psychiatric Status Rating Scales Diazepam Hepatology medicine.diagnostic_test business.industry Biopsy Needle Gastroenterology Hepatitis C Middle Aged medicine.disease Analgesics Opioid Anti-Anxiety Agents Liver Liver biopsy Anesthesia Female Analgesia business medicine.drug |
| Zdroj: | European Journal of Gastroenterology & Hepatology. 23:782-786 |
| ISSN: | 0954-691X |
| DOI: | 10.1097/meg.0b013e328348d619 |
| Popis: | Introduction Liver biopsy remains the gold standard for the diagnosis and staging of liver diseases. Despite being painful, analgesia before liver biopsy is usually avoided due to the notion that pain is minor and due to the concern of masking possible abdominal symptoms. Postbiopsy pain levels were previously mapped for the purpose of analgesia planning. Aim To compare pain and anxiety levels between two prophylactic treatment regimens, a combination of sublingual tramadol Hcl with oral lorazepam and oral diazepam only. Patients and methods One hundred and thirteen consecutive patients were selected to receive either prophylactic analgesia with sublingual tramadol Hcl (50 mg) flashtabs and oral lorazepam [(1 mg) analgesia group (AG), n = 56] or oral diazepam (5 mg) alone [nonAG (NAG), n = 57]. Pain and anxiety levels were assessed using Visual Analogue Scale (1-10) and State Anxiety Inventory, respectively, 30 min before, and 30 min and 6 h after the biopsy. Results The groups were comparable with respect to baseline characteristics. Thirty minutes after the procedure, pain levels were significantly lower in the AG (mean Visual Analogue Scale ± standard error of the mean, 1.8±0. 3; median = 1 ) compared with the NAG (3.1 ±0.3, median = 3 ; P 7) compared with the patients in the AG (3.6%; P=0.09). Six hours after the procedure, pain intensity remained significantly lower in the AG compared with the NAG (0.8 ± 0.1 vs. 1.5 ± 0.2; P< 0.005). Anxiety levels were comparable. Conclusion Prophylactic combination of short-acting tramadol and lorazepam is effective, safe, and can be used routinely before liver biopsy. |
| Databáze: | OpenAIRE |
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