Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression
| Autor: | Paul A. Reynolds, Frank J. Gunn-Moore, Adam J. Gersten, Susana Moleirinho, Michael B. Prystowsky, Yanghua Wang |
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| Přispěvatelé: | The Melville Trust for the Care & Cure, University of St Andrews. School of Biology, University of St Andrews. School of Medicine, University of St Andrews. Institute of Behavioural and Neural Sciences, University of St Andrews. Biomedical Sciences Research Complex |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
squamous cell carcinoma
Pathology medicine.medical_specialty Cell Perineural invasion NDAS Biology Article fibroblast Pathology and Forensic Medicine RC0254 Stroma SDG 3 - Good Health and Well-being Transcription (biology) Squamous cell carcinoma medicine lcsh:Pathology Fibroblast RC0254 Neoplasms. Tumors. Oncology (including Cancer) perineural invasion medicine.disease Head and neck squamous-cell carcinoma medicine.anatomical_structure Phosphorylation Immunohistochemistry YAP expression lcsh:RB1-214 |
| Zdroj: | Academic Pathology, Vol 2 (2015) Academic pathology |
| Popis: | Paul A. Reynolds, PhD, is supported by the Melville Trust for the Care and cure of Cancer. We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with perineural invasion show higher levels of nuclear YAP compared to fibroblasts in the stroma of normal mucosa, with a median cell count of 35.4 per high-power field in the former and 3.9 in the latter. No differences were observed between the expression of YAP phosphorylated at Ser127 in the tumoral stroma compared to that in the normal mucosa, with a median cell count expression of 4.9 in the former versus 5.0 in the latter. Therefore, a strong and increased nuclear YAP expression in fibroblasts associated with perineural invasion in head and neck squamous cell carcinoma suggests that YAP-mediated transcription programs in these fibroblasts may contribute to perineural invasion. Postprint Publisher PDF |
| Databáze: | OpenAIRE |
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