Effect on Long-Term Mortality of HLA-DR Matching in Heart Transplantation
| Autor: | Claudio Napoli, Chiara Sabia, Giampaolo Romano, Irene Mattucci, Pasquale Abete, Ciro Maiello, C. Marra, Francesco Cacciatore, Cristiano Amarelli |
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| Přispěvatelé: | Cacciatore, Francesco, Amarelli, Cristiano, Sabia, Chiara, Mattucci, Irene, Marra, Claudio, Romano, Giampaolo, Abete, Pasquale, Maiello, Ciro, Napoli , Claudio |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Heart transplantation
Heart Failure Male Pediatrics medicine.medical_specialty Matching (statistics) business.industry medicine.medical_treatment HLA-DR Antigens Middle Aged Histocompatibility HLA-DR medicine Heart Transplantation Humans Long term mortality Female Cardiology and Cardiovascular Medicine business Follow-Up Studies Retrospective Studies |
| Popis: | Human leukocyte antigen (HLA) matching exerts a protective effect in organ transplantation, ensuring better graft function, fewer episodes of rejection, longer graft survival, and the possibility of lower immunosuppression.1, 2, 3 However, the precise influence of HLA incompatibility in heart transplants remains to be determined, and prospective HLA matching is seldom achieved. We previously demonstrated that the odds of in-hospital mortality after heart transplantation is greater in the case of HLA-DR mismatch.4 The goal of the present study was to evaluate the effect of DR mismatch on long-term mortality. |
| Databáze: | OpenAIRE |
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