Growth in agar and tumor formation in immunologically incompetent mice as criteria for keratinocyte transformation
| Autor: | Jennifer Knight, Gerard Cowley, Barry A. Gusterson |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty food.ingredient Single cell suspension Cell Mice Nude Biology Malignant transformation Cell Line Mice food medicine Agar Animals Humans Cells Cultured Skin Molecular biology Tumor formation stomatognathic diseases Transformation (genetics) medicine.anatomical_structure Cell Transformation Neoplastic Oncology Cell culture Carcinoma Squamous Cell Keratinocyte Immunocompetence Neoplasm Transplantation |
| Zdroj: | Cancer letters. 21(1) |
| ISSN: | 0304-3835 |
| Popis: | Established cell lines from 8 human squamous cell carcinomas (SCC) together with normal human keratinocytes, have been investigated for their ability to grow in soft agar and as xenografts when injected as a single cell suspension into immunologically incompetent mice. One of 8 SCC lines formed colonies with efficiencies greater than 1% in soft agar, and only 2 formed progressively growing tumors when injected into animals. It is concluded that these 2 criteria are not reliable markers of malignant transformation in squamous epithelia unless cytological criteria are also applied. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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