Siglec15 Checkpoint Blockade for Simultaneous Immunochemotherapy and Osteolysis Inhibition in Lung Adenocarcinoma Spinal Metastasis via a Hollow Nanoplatform

Autor:	Haifeng Liang, Lei Zhou, Zhichao Hu, Yuxiang Ge, Taiwei Zhang, Qing Chen, Ben Wang, Shunyi Lu, Wang Ding, Jian Dong, Fengfeng Xue, Libo Jiang
Rok vydání:	2022
Předmět:	Biomaterials Mice Lung Neoplasms Spinal Neoplasms Manganese Compounds Tumor Microenvironment Animals General Materials Science Adenocarcinoma of Lung Oxides General Chemistry Osteolysis Biotechnology
Zdroj:	Small (Weinheim an der Bergstrasse, Germany). 18(29)
ISSN:	1613-6829
Popis:	Low responsiveness to anti-programmed death-1/programmed death-ligand 1 (anti-PD-1/PD-L1) for solid tumors indicates the presence of other immunosuppressive pathways. Siglec15, a newly discovered immune checkpoint, has been reported to repress immune responses in the tumor microenvironment (TME) and regulate osteoclast differentiation. However, the role of Siglec15 in the treatment for bone metastasis remains unclear. Herein, Siglec15 shows significantly higher expression in lung adenocarcinoma spinal metastasis (LUAD-SM) than in para-cancerous spinal tissues and primary LUAD. Subsequently, a TME-responsive hollow MnO
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427d3efc78ccdd6b5af1812f0a39327f https://pubmed.ncbi.nlm.nih.gov/35751455 Zobrazit plný text záznamu Plný text