PVF2, a PDGF/VEGF‐like growth factor, induces hemocyte proliferation in Drosophila larvae
| Autor: | Charles A. Janeway, Marie Lagueux, Marie Meister, Jules A. Hoffmann, Emmanuel Perrodou, Daniel Doucet, Daniel Zachary, Anne-Isabelle Munier |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Hemocytes
medicine.medical_treatment Cellular differentiation Blotting Western Scientific Report Biology Ligands Biochemistry Antibodies Blood cell chemistry.chemical_compound Genetics medicine Animals Receptors Platelet-Derived Growth Factor Receptor Molecular Biology Cell growth Growth factor Cell Differentiation Immunohistochemistry Hemocyte proliferation Cell biology Vascular endothelial growth factor Receptors Vascular Endothelial Growth Factor medicine.anatomical_structure chemistry Larva biology.protein Drosophila Platelet-derived growth factor receptor |
| Zdroj: | EMBO reports. 3:1195-1200 |
| ISSN: | 1469-3178 1469-221X |
| DOI: | 10.1093/embo-reports/kvf242 |
| Popis: | Blood cells play a crucial role in both morphogenetic and immunological processes in Drosophila, yet the factors regulating their proliferation remain largely unknown. In order to address this question, we raised antibodies against a tumorous blood cell line and identified an antigenic determinant that marks the surface of prohemocytes and also circulating plasmatocytes in larvae. This antigen was identified as a Drosophila homolog of the mammalian receptor for platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF). The Drosophila receptor controls cell proliferation in vitro. By overexpressing in vivo one of its putative ligands, PVF2, we induced a dramatic increase in circulating hemocytes. These results identify the PDGF/VEGF receptor homolog and one of its ligands as important players in Drosophila hematopoiesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text