Colonoscopic findings in coeliac disease on a gluten-free diet
| Autor: | Giovanni Casella, Gabrio Bassotti, Vincenzo Villanacci, E. de Marco, Vittorio Baldini, Fabio Pagni, C. Di Bella, E. Drera, R. Ortenzi |
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| Přispěvatelé: | Casella, G, Villanacci, V, Di Bella, C, de Marco, E, Pagni, F, Drera, E, Ortenzi, R, Baldini, V, Bassotti, G |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Lymphocytic colitis Anemia Colonoscopy Gastroenterology Coeliac disease Diet Gluten-Free Internal medicine Melanosis coli medicine Humans lcsh:RC799-869 Colitis Aged Retrospective Studies medicine.diagnostic_test business.industry General Medicine Iron deficiency Middle Aged medicine.disease digestive system diseases Celiac Disease lcsh:Diseases of the digestive system. Gastroenterology Female Gluten free business Coliti |
| Zdroj: | Revista Española de Enfermedades Digestivas v.102 n.9 2010 SciELO España. Revistas Científicas Españolas de Ciencias de la Salud instname Revista Española de Enfermedades Digestivas, Volume: 102, Issue: 9, Pages: 538-541, Published: SEP 2010 Scopus-Elsevier Revista Espanola de Enfermedades Digestivas, Vol 102, Iss 9, Pp 538-541 (2010) |
| Popis: | Background: to date, there are few data on colonoscopic findings in patients with celiac disease, and most of these obtained in patients with iron deficiency anaemia. Aims: we assessed colonoscopic findings in unselected pa tients with coeliac disease, since there are no studies available also considering morphological aspects, and there is literature sugges tion of increased prevalence of colorectal tumours. Material and methods: colonoscopies with multiple biopsies were retrospectively analyzed in 42 coeliac disease patients on gluten-free diet above age 40; 16 had clinical or laboratory fea tures of iron deficiency anaemia. Mucosal biopsies were evaluated for the presence of intraepithelial lymphocytes and of mucosal eosinophils, in addition to conventional histologic assessment, and compared with those obtained in 15 controls. Results: macroscopic abnormalities (polyps, diverticula, in flammatory changes) were found in 26% of patients. Microscopic abnormalities (lymphocytic colitis, melanosis coli, rectal histiocyto sis) were found in 36% of patients. None of these findings was found in controls. Coeliac disease patients had significantly higher eosinophil score than controls in the right colon, whereas this was not significantly different between groups in the left colon. Conclusions: colonoscopic findings in coeliac disease on gluten-free diet may reveal significant findings, even in patients without iron deficiency anaemia. There is the need of further stud ies in larger cohorts of patients to establish whether colonoscopy in these patients may be clinically useful. |
| Databáze: | OpenAIRE |
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