High prevalence of occult hepatitis B infection (OBI) among healthy children and their parents in Alborz province, Iran; Vertical OBI, myth or truth?
| Autor: | Mehdi Norouzi, Zahra Fakhari, Vahdat Poortahmasebi, Mohammad Farahmand, Mojtaba Hedayat Yaghoobi, Seyed Mohammad Jazayeri, Azam Ghaziasadi, Leila Ghalichi, Mehrdad Ravanshad, Bahman Aghcheli, Alireza Soleimani |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Parents Hepatitis B virus medicine.medical_specialty HBsAg Adolescent Population Iran medicine.disease_cause Polymerase Chain Reaction law.invention 03 medical and health sciences 0302 clinical medicine law Internal medicine Prevalence medicine Humans Hepatitis B Vaccines Hepatitis B Antibodies Child education Polymerase chain reaction education.field_of_study High prevalence Hepatology Transmission (medicine) business.industry Vaccination virus diseases Occult hepatitis B infection Viral Load Hepatitis B digestive system diseases Cross-Sectional Studies 030220 oncology & carcinogenesis DNA Viral Female 030211 gastroenterology & hepatology business Viral load |
| Zdroj: | Liver International. 40:92-100 |
| ISSN: | 1478-3231 1478-3223 |
| Popis: | BACKGROUND Occult hepatitis B infection (OBI) has been described in various clinical settings including after hepatitis B virus (HBV) immunization. The purpose of study was to characterize the prevalence of OBI among immunized children from a subset of general population and the parents of OBI-positive cases. METHODS Sera of 1200 children from general population who have been previously immunized by HBV vaccine were assayed for anti-HBs. 660 were randomly selected for HBV DNA testing by different polymerase chain reaction (PCR) methods and were analysed by direct sequencing on surface genes. RESULTS None of participants were positive for HBsAg and anti-HBc. 549 (45.7%) and 651 (54.3%) cases had anti-HBs > 10 mIU/mL (responders) and |
| Databáze: | OpenAIRE |
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