Comparative study of SCE induction and cytostatic effects by homo-azasteroidal esters of N,N-bis(2-chloroethyl)aminobenzoic acid in human lymphocytes
| Autor: | Dionysios Mourelatos, A. Paradelis, A. Anastasiou, L. Boutis, Athanasios A. Papageorgiou, E. Mylonaki, Panayotis Catsoulacos |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Cell division
Stereochemistry Antineoplastic Agents Sister chromatid exchange Biological activity General Medicine chemistry.chemical_compound chemistry Biochemistry Azasteroids Nitrogen Mustard Compounds Toxicity Lactam Humans Potency Aminobenzoic acid Lymphocytes Sister Chromatid Exchange Cell Division Cells Cultured Mutagens Benzoic acid |
| Zdroj: | Mutation Research Letters. 346:129-133 |
| ISSN: | 0165-7992 |
| DOI: | 10.1016/0165-7992(95)90044-6 |
| Popis: | The effect of homo-azasteroidal esters of benzoic acid mustard isomers and the 4-methyl derivatives, which have steroidal lactams as a biological basis, on cytogenetic damage was studied. Twenty compounds were comparatively studied, on a molar basis, as regards their ability to induce sister-chromatid exchanges (SCEs) and cell division delays. A correlation between potency for SCE induction, effectiveness in cell division delay and previously established antitumor activity of these compounds was observed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect