IgM MGUS associated with anti-MAG neuropathy: a single institution experience
| Autor: | Giampaolo Talamo, Jeffrey Sivik, Muhammad A. Mir, Divisha Raheja, Manoj K. Pandey |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Monoclonal Gammopathy of Undetermined Significance Polyneuropathies immune system diseases hemic and lymphatic diseases Internal medicine medicine Humans cardiovascular diseases Single institution Aged Retrospective Studies Hematology business.industry Anti mag Cancer Retrospective cohort study General Medicine Middle Aged medicine.disease Antibodies Anti-Idiotypic Surgery IgM Monoclonal Gammopathy Peripheral neuropathy Immunoglobulin M nervous system Female Rituximab business Biomarkers medicine.drug |
| Zdroj: | Annals of Hematology. 94:1011-1016 |
| ISSN: | 1432-0584 0939-5555 |
| DOI: | 10.1007/s00277-014-2294-7 |
| Popis: | Anti-MAG neuropathy is a very rare form of acquired polyneuropathy associated with IgM monoclonal gammopathy of undetermined significance (MGUS). We conducted a retrospective review of 194 consecutive MGUS patients seen at the Penn State Hershey Cancer Institute. We identified six patients among 37 (16 %) with IgM MGUS with anti-MAG neuropathy. Interestingly, an additional patient had anti-MAG neuropathy without MGUS. Common clinical manifestations were numbness and paresthesias of the extremities and gait imbalance. All four patients treated with rituximab and none of the three untreated ones had a subjective improvement of their symptoms. We conclude that all patients with IgM MGUS and neuropathy should be screened for anti-MAG antibodies and, if positive, they should be offered treatment with rituximab. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink