Role of the kallikrein–kinin system in Ang-(1-7)-induced vasodilation in mesenteric arterioles of Wistar rats studied in vivo–in situ
| Autor: | Rossana Anderson Marangoni, Rita de Cássia Aleixo Tostes Passaglia, Dorothy Nigro, Maria Helena Catelli de Carvalho, Zuleica Bruno Fortes, Adriana K. Carmona |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Kallikrein-Kinin System Physiology Bradykinin Vasodilation Biochemistry Microcirculation Cellular and Molecular Neuroscience chemistry.chemical_compound Aprotinin Endocrinology Arteriole Internal medicine medicine.artery Renin–angiotensin system Serine medicine Animals Cysteine Rats Wistar Chemistry Kinin Rats Arterioles cardiovascular system Kallikreins hormones hormone substitutes and hormone antagonists Intravital microscopy Peptide Hydrolases medicine.drug |
| Zdroj: | Peptides. 27:1770-1775 |
| ISSN: | 0196-9781 |
| Popis: | Angiotensin-(1-7) [Ang-(1-7)], exerts a variety of actions in the cardiovascular system, with an important effect being vasodilation. In this work, we investigated the relationship between the vasodilatory activity of Ang-(1-7) and the kallikrein-kinin system. Intravital microscopy was used to study the vasodilation caused by Ang-(1-7) in the mesenteric vascular bed of anesthetized Wistar rats. The topical application of Ang-(1-7) caused vasodilation of mesenteric arterioles that was reduced by A-779, JE 049 and peptidase inhibitors (aprotinin, SBTI, PKSI 527, E-64, PMSF). These results indicated that the vasodilation induced by Ang-(1-7) in the mesenteric arterioles of Wistar rats was heavily dependent on the activation of kallikrein and subsequent kinin formation. |
| Databáze: | OpenAIRE |
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