Breast Implant-Associated Anaplastic Large-Cell Lymphoma: Long-Term Follow-Up of 60 Patients
| Autor: | Jorge J. Castillo, Dennis P. O'Malley, Daphne de Jong, John A. Keech, Alonso R. Miranda, Ken H. Young, Steven Sanchez, John T. Manning, Nisreen Haideri, Tariq N. Aladily, Roland L. Bassett, H. Miles Prince, Govind Bhagat, Matthew J. Carty, Summer E. Hanson, Zijun Y. Xu-Monette, Douglas P. Clark, Ephram P. Hochberg, Patricia S. Fox, Roberto N. Miranda, Luis Fayad, Zaher Chakhachiro, Glen S. Brooks, Chan Yoon Cheah, Shiyong Li, Eid Mustafa, Rashmi Kanagal-Shamanna, David A. Shifrin, Gabriela Gualco, Dongjiu Ye, Brady E Beltran, Mitual Amin, L. Jeffrey Medeiros, Carlos E. Bacchi, Jan de Boer |
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| Přispěvatelé: | Pathology, CCA - Innovative therapy |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Time Factors Breast surgery medicine.medical_treatment Breast Implants Breast Neoplasms Disease-Free Survival law.invention Drug Therapy law Internal medicine medicine Humans Breast Watchful Waiting Anaplastic large-cell lymphoma Device Removal Aged Aged 80 and over business.industry Large cell ORIGINAL REPORTS Middle Aged medicine.disease Lymphoma Natural history Breast implant Lymphoma Large-Cell Anaplastic Female Implant business Watchful waiting Follow-Up Studies |
| Zdroj: | Journal of Clinical Oncology, 32(2), 114-120. American Society of Clinical Oncology Miranda, R N, Aladily, T N, Prince, H M, Kanagal-Shamanna, R, de Jong, D, Fayad, L E, Amin, M B, Haideri, N, Bhagat, G, Brooks, G S, Shifrin, D A, O'Malley, D P, Cheah, C Y, Bacchi, C E, Gualco, G, Li, S Y, Keech, J A, Hochberg, E P, Carty, M J, Hanson, S E, Mustafa, E, Sanchez, S, Manning, J T, Xu-Monette, Z Y, Miranda, A R, Fox, P, Bassett, R L, Castillo, J J, Beltran, B E, de Boer, J P, Chakhachiro, Z, Ye, D J, Clark, D, Young, K H & Medeiros, L J 2014, ' Breast Implant-Associated Anaplastic Large-Cell Lymphoma: Long-Term Follow-Up of 60 Patients ', Journal of Clinical Oncology, vol. 32, no. 2, pp. 114-120 . https://doi.org/10.1200/JCO.2013.52.7911 |
| ISSN: | 0732-183X |
| Popis: | Purpose Breast implant–associated anaplastic large-cell lymphoma (ALCL) is a recently described clinicopathologic entity that usually presents as an effusion-associated fibrous capsule surrounding an implant. Less frequently, it presents as a mass. The natural history of this disease and long-term outcomes are unknown. Patients and Methods We reviewed the literature for all published cases of breast implant–associated ALCL from 1997 to December 2012 and contacted corresponding authors to update clinical follow-up. Results The median overall survival (OS) for 60 patients was 12 years (median follow-up, 2 years; range, 0-14 years). Capsulectomy and implant removal was performed on 56 of 60 patients (93%). Therapeutic data were available for 55 patients: 39 patients (78%) received systemic chemotherapy, and of the 16 patients (28%) who did not receive chemotherapy, 12 patients opted for watchful waiting and four patients received radiation therapy alone. Thirty-nine (93%) of 42 patients with disease confined by the fibrous capsule achieved complete remission, compared with complete remission in 13 (72%) of 18 patients with a tumor mass. Patients with a breast mass had worse OS and progression-free survival (PFS; P = .052 and P = .03, respectively). The OS or PFS were similar between patients who received and did not receive chemotherapy (P = .44 and P = .28, respectively). Conclusion Most patients with breast implant–associated ALCL who had disease confined within the fibrous capsule achieved complete remission. Proper management for these patients may be limited to capsulectomy and implant removal. Patients who present with a mass have a more aggressive clinical course that may be fatal, justifying cytotoxic chemotherapy in addition to removal of implants. |
| Databáze: | OpenAIRE |
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