Use of WIN 51711 to prevent echovirus type 9-induced paralysis in suckling mice
| Autor: | M. A. McKinlay, D. P. Benziger, B. A. Steinberg, J. A. Frank |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Myocarditis
Echovirus Administration Oral Echovirus Infections medicine.disease_cause Antiviral Agents Mice medicine Paralysis Immunology and Allergy Animals Tissue Distribution Oxazoles Respiratory tract infections Neonatal sepsis business.industry Acute hemorrhagic conjunctivitis Aseptic meningitis Isoxazoles medicine.disease Virology Animals Suckling Infectious Diseases Echovirus 9 Immunology Enterovirus medicine.symptom business Injections Intraperitoneal |
| Zdroj: | The Journal of infectious diseases. 154(4) |
| ISSN: | 0022-1899 |
| Popis: | liver, serum (ng/ml), and muscle, respectively at 0.5-1.0 hr after medication. The picornaviruses, a group of small, single-stranded RNA viruses, are the causative agents of several disease states. Among the picornaviridae are two groups that cause disease in humans: the enteroviruses and the rhinoviruses. The enterovirus group consists of 68 distinct serotypes that have been associated with many diverse disease states, including poliomyelitis, neonatal sepsis, aseptic meningitis, pericarditis, myocarditis, hepatitis, acute hemorrhagic conjunctivitis, and upper respiratory tract infections. WIN 51711, 5-[7-[4-(4,5-dihydro-2-oxazolyl)phenoxy]heptyl]-3-methylisoxazole, is effective in preventing poliovirus-induced paralysis and death when administered orally to mice at levels as low as 16 mg/kg per dose, twice a day. The protective effect of the compound was attributed to a marked reduction in the titer of virus in the CNS of medicated mice [1]. The present study was designed to assess the effect of WIN 51711 on infection of suckling mice with echovirus type 9. Previous studies have shown that mouse pups infected within the first 24 hr of birth will develop a flaccid limb paralysis after develop |
| Databáze: | OpenAIRE |
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