Efficacy of pentasaccharide on a prethrombosis model based on a calibrated stasis by the increase in up-stream venous pressure
| Autor: | J M Herbert, N Passuti, F Truchaud, Pierre Pottier, L Bressollette, G Leftheriotis, Bernard Planchon |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_treatment Antithrombin III Blood Pressure Inferior vena cava Thromboplastin Rats Sprague-Dawley Thrombogen Polysaccharides Animals Thrombophilia Medicine Ligature Hemostasis Dose-Response Relationship Drug business.industry Venous pressure Low dose Central venous pressure Thrombosis Hematology General Medicine medicine.disease Rats Disease Models Animal Treatment Outcome Fondaparinux medicine.vein Anesthesia cardiovascular system business Peptide Hydrolases |
| Zdroj: | Blood Coagulation & Fibrinolysis. 14:587-591 |
| ISSN: | 0957-5235 |
| DOI: | 10.1097/00001721-200309000-00011 |
| Popis: | On a previous model using Wessler's principle in the rat, we have demonstrated that a partial ligature of the inferior vena cava leading to a 40% increase in up-stream venous pressure was thrombogenic only in association with the infusion of low dose of thromboplastin (90 microg/kg). In these thrombogenic conditions, the infusion of pentasaccharide (Arixtra, fondaparinux) should lead to a strong inhibition of thrombus formation. Therefore, we performed on five groups of 10 rats: stasis alone (group S) with a 40% increase in up-stream venous pressure; stasis and thromboplastin (group ST90); and stasis, thromboplastin and pentasaccharide (groups SPT50, SPT100 and SPT250) at three different dosages (50, 100 and 250 microg/kg). The efficacy of pentasaccharide was measured according to the variations in up-stream venous pressure, thrombus weight and thrombin-antithrombin complexes levels. Only 250 microl/kg pentasaccharide significantly reduced the thrombus weight in comparison with group ST90 (5 mg versus 23.8 mg, P = 0.01) but it was not sufficient to induce a return to the basic state (5 mg versus 0.2 mg in group S, P = 0.049). Thrombin-antithrombin complex levels measured at the end of the experiment were significantly reduced in comparison with group ST90 (16.7 versus 57.8 mg, P = 0.01) and were not statistically different from group S (16.1 versus 16.6 mg, P = 0.65). In conclusion, in a very borderline model toward thrombogenesis, pentasaccharide was able to reduce thrombus weight and abolished biological hypercoagulability. |
| Databáze: | OpenAIRE |
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