Severe Cardiotoxicity in a Patient with Colorectal Cancer Treated with Bevacizumab
| Autor: | Peng Li, Jian Chen, Zhaohua Gong, Fengcai Du, Hongjin Chu, Lixin Jiang, Baohong Hu, Cheng Chi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Cancer Research
medicine.medical_specialty Heart Diseases genetic structures Bevacizumab Colorectal cancer Biopsy medicine.medical_treatment Angiogenesis Inhibitors Antineoplastic Agents 030204 cardiovascular system & hematology 01 natural sciences Pericardial effusion 03 medical and health sciences 0302 clinical medicine Internal medicine Antineoplastic Combined Chemotherapy Protocols Humans Medicine Chemotherapy Cardiotoxicity business.industry Colonoscopy General Medicine Middle Aged medicine.disease Thrombosis Pulmonary hypertension 0104 chemical sciences 010404 medicinal & biomolecular chemistry Regimen Oncology Female Colorectal Neoplasms Tomography X-Ray Computed business Biomarkers medicine.drug |
| Zdroj: | Anticancer Research. 37 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | Background/aim Bevacizumab combined with standard chemotherapeutics has become a choice of treatment for several kinds of cancers. Hypertension, third-degree albuminuria, thrombosis and cardiotoxicity are the reported side-effects of bevacizumab. Among them, cardiotoxicity is a most severe, but rare outcome. We report a case of a 62-year-old female with colorectal carcinoma who was given bevacizumab-containing chemotherapy for more than 20 months and achieved a stable disease during the entire course of treatment. Thereafter, she developed cardiotoxicity including grade 3 hypertension, tricuspid regurgitation, pulmonary hypertension, left ventricular diastolic dysfunction and pericardial effusion, and was discontinued from the regimen with bevacizumab. Conclusion Although clinically-effective, the severe cardiotoxicity of bevacizumab developed after over 20 courses of treatment prompted us to look for optimal chemotherapy prescription in order to achieve a better clinical outcome. |
| Databáze: | OpenAIRE |
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