Repeated doses of combined oral lysine acetylsalicylate and metoclopramide in the acute treatment of migraine
| Autor: | J. Danchot, J.‐P. Lacoste, J.‐E. Joire, F.‐C. Hugues |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Metoclopramide medicine.medical_treatment Migraine Disorders Central nervous system disease medicine Humans Chemotherapy Analgesics Aspirin Vascular disease business.industry Lysine Middle Aged medicine.disease Rescue medication Drug Combinations Neurology Migraine Repeated doses Anesthesia Lysine acetylsalicylate Acute Disease Dopamine Antagonists Female Neurology (clinical) business medicine.drug |
| Zdroj: | Headache. 37(7) |
| ISSN: | 0017-8748 |
| Popis: | The combination of lysine acetylsalicylate and metoclopramide is effective in the treatment of migraine attacks. It was unknown whether repeated doses could improve efficacy. The aim of this open trial was to evaluate the effects of a second, and eventually a third dose of lysine acetylsalicylate and metoclopramide when a first dose of the treatment was ineffective. Patients were asked to take a second dose 2 hours after a first dose when they thought that the first dose was ineffective. They were allowed to take a third dose or their rescue medication 2 hours after the second dose when they judged that the treatment remained ineffective. Two hundred ninety-two patients were included in the study; 262 of the 292 patients treated 517 attacks. Headache relief (reduction in headache severity from grade 3 or 2 to grade 1 or 0) was observed in 54.8% of attacks after one dose, in 48.1% of attacks after a second dose, and in 40.3% of attacks after a third dose. Complete headache relief without recurrence and without use of a rescue medication was reported in 37% of the total attacks. The patients judged their treatment as good or excellent in 78% of attacks treated with one dose, in 41% of those treated with two doses, and in 19% of those treated with three doses. Tolerance, as judged by the patients, was considered good in 92% of treated attacks. Minor side effects occurred in 6% of attacks after a first dose, in 4.5% of attacks after a second dose, in 1.5% of attacks after a third dose, in 2% after unspecified delay, and in 14% overall. In conclusion, the efficacy of lysine acetylsalicylate and metoclopramide in the treatment of migraine attacks can be improved by repeated doses. It is well tolerated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text