Population-based estimates of humoral autoimmunity from the U.S. National Health and Nutrition Examination Surveys, 1960–2014

Autor: Michael H. Weisman, Frederick W. Miller, Charles Dillon
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Databases
Factual
Physiology
Extractable nuclear antigens
Cross-sectional study
Autoimmunity
Biochemistry
Geographical locations
Endocrinology
0302 clinical medicine
Immune Physiology
Medicine and Health Sciences
Medicine
Young adult
Thyroid
education.field_of_study
Immune System Proteins
Multidisciplinary
Middle Aged
Nutrition Surveys
Anti-thyroid autoantibodies
3. Good health
Female
Anatomy
Research Article
Adult
Adolescent
National Health and Nutrition Examination Survey
Endocrine Disorders
Science
Immunology
Population
Endocrine System
Rheumatoid Arthritis
Antibodies
Autoimmune Diseases
Young Adult
03 medical and health sciences
Rheumatology
Diabetes Mellitus
Humans
Rheumatoid factor
education
Autoantibodies
Nutrition
Aged
030203 arthritis & rheumatology
business.industry
Arthritis
Autoantibody
Biology and Life Sciences
Proteins
Health Surveys
United States
Immunity
Humoral
Cross-Sectional Studies
030104 developmental biology
Metabolic Disorders
North America
Clinical Immunology
Clinical Medicine
People and places
business
Demography
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 1, p e0226516 (2020)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0226516
Popis: Objective Based on US National Health and Nutrition Examination Survey (NHANES) data, we attempted to provide an unbiased, population-based estimate of autoantibody prevalence overall and by age and sex. Methods US autoantibody prevalence estimates for detectable rheumatoid factor, anti-thyroglobulin, anti-thyroperoxidase, anti-transglutaminase, anti-endomysial, anti-GAD65, antinuclear autoantibodies, and autoantibodies to extractable nuclear antigens were estimated from the 1960-1962 National Health Examination Survey, NHANES III (1988-1994), and the NHANES 1999-2014 cross-sectional surveys. Survey design variables and sample weights were used to account for differential probabilities of selection within the complex survey design. Data analysis used SASTM and SUDAAN™ software. US Census Bureau data were used to estimate the absolute numbers of persons with autoantibodies. Results NHANES III data show that the overall US prevalence of having a detectable serum autoantibody is substantial in adults, in both women and men. Thyroid autoantibodies were present in 18% of US adults (31 million persons) including 10% of younger adults and 25% of older persons. Overall autoantibody prevalences increased significantly with age: 32% of US adults 60+ years of age (12.8 million persons) had at least one of the four autoantibodies rheumatoid factor, anti-thyroglobulin, anti-thyroperoxidase, or anti-tissue transglutaminase. Older women had higher levels of autoantibodies, but this was a relative difference. Autoantibody prevalence in both sexes was substantial (women 39%; men 22%). Fourteen percent of adults 60+ years of age have multiple autoantibodies. Conclusions Autoantibodies are present in a significant fraction of the general population, especially in older adults and women relative to men. Although all known clinically significant autoantibodies were not analyzed, these data provide an important population perspective on the scope and magnitude of humoral autoimmunity in the US. This is vital for prevention efforts to reduce autoimmune disease and helps clarify the potential impact of autoimmunity on the general population.
Databáze: OpenAIRE
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