Overview of Nonhuman Primate Models of SARS-CoV-2 Infection
| Autor: | Anita M. Trichel |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Primates
COVID-19 Vaccines General Veterinary Coronavirus disease 2019 (COVID-19) biology business.industry SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Overview COVID-19 Disease biology.organism_classification General Biochemistry Genetics and Molecular Biology World health Nonhuman primate Immunology Pandemic Global health Medicine Animals Humans business Pandemics Betacoronavirus |
| Zdroj: | Comp Med |
| ISSN: | 2769-819X |
| Popis: | COVID-19, the disease caused by the SARS-CoV-2 betacoronavirus, was declared a pandemic by the World Health Organization on March 11, 2020. Since then, SARS-CoV-2 has triggered a devastating global health and economic emergency. In response, a broad range of preclinical animal models have been used to identify effective therapies and vaccines. Current animal models do not express the full spectrum of human COVID-19 disease and pathology, with most exhibiting mild to moderate disease without mortality. NHPs are physiologically, genetically, and immunologically more closely related to humans than other animal species; thus, they provide a relevant model for SARS-CoV-2 investigations. This overview summarizes NHP models of SARS-CoV-2 and their role in vaccine and therapeutic development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|