The prevalence of non organ specific and thyroid autoimmunity in patients with polycystic ovary syndrome
| Autor: | Zuzana Vaczy, Ivica Lazúrová, Ingrid Dravecká, Jana Figurová, Darina Kozakova, Jan Rosocha, Jana Petríková, Jana Vrbikova |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent endocrine system diseases lcsh:Medicine Autoimmunity Enzyme-Linked Immunosorbent Assay medicine.disease_cause Gastroenterology systemic autoantibodies General Biochemistry Genetics and Molecular Biology hyperandrogenism Autoimmune thyroiditis Young Adult Internal medicine medicine Humans Endocrine system Autoantibodies biology business.industry lcsh:R Hyperandrogenism Thyroiditis Autoimmune Autoantibody Middle Aged medicine.disease Polycystic ovary female genital diseases and pregnancy complications Case-Control Studies Immunoglobulin G Immunology Thyroid autoimmunity biology.protein Female autoimmune thyroid disease Antibody business Polycystic Ovary Syndrome |
| Zdroj: | Biomedical Papers, Vol 159, Iss 2, Pp 302-306 (2015) |
| ISSN: | 1804-7521 1213-8118 |
| DOI: | 10.5507/bp.2014.062 |
| Popis: | Background: Polycystic ovary syndrome (PCOS) is commonly associated with endocrine, metabolic, cardiovascular and other morbidities. However its association with autoimmune diseases is still controversial. Aim: The aim of this study was to assess the prevalence of non organ-specific and antithyroid, antibodies in PCOS women compared to healthy controls. Methods: The study included 152 women with PCOS and 76 healthy controls for the evaluation of non organ-specific autoimmunity and 64 PCOS and 68 controls for the study of organ-specific autoimmunity. All sera were tested for autoantibodies.using the ELISA method. Results: There were no significant differences in the prevalence of ANA, SSA, SSB, anti-dsDNA, anti-RNP, ANCA/MPO or ANCA/PR3 between PCOS and controls. The prevalence of ACLA IgG was higher in controls than PCOS (5.4% v.s. 0%, P=0.011). Patients had a higher prevalence of anti-TPO antibodies (18.75% v.s. 7.35%, P=0.045) and slightly but not significantly higher prevalence of autoimmune thyroiditis (18.75% v.s. 10.29%) than controls. Conclusion: The prevalence of non organ-specific autoantibodies in PCOS women is low and similar to controls. On the other hand, we found a slightly higher prevalence of thyroid autoimmunity in PCOS women. |
| Databáze: | OpenAIRE |
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