miRNA dysregulation in ischaemic stroke: Focus on diagnosis, prognosis, therapeutic and protective biomarkers
| Autor: | Anjana Munshi, Kanika Vasudeva |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Early detection
Disease Bioinformatics medicine.disease_cause Brain Ischemia 03 medical and health sciences 0302 clinical medicine microRNA Ischaemic stroke Medicine Humans Stroke 030304 developmental biology Ischemic Stroke 0303 health sciences business.industry General Neuroscience medicine.disease Prognosis MicroRNAs Apoptosis Biomarker (medicine) business 030217 neurology & neurosurgery Oxidative stress Biomarkers |
| Zdroj: | The European journal of neuroscienceREFERENCES. 52(6) |
| ISSN: | 1460-9568 |
| Popis: | Stroke is one of the leading causes of death and disability in both developing and developed countries. Biomarkers for stroke and its outcome can greatly facilitate early detection and management of the disease. miRNAs have been explored for their potential as biomarkers for diagnosis, prognosis and brain injury in ischaemic stroke. A substantial body of evidence suggests that miRNAs play key roles in numerous cellular changes following ischaemic stroke including mitochondrial dysfunction, energy failure, cytokine-mediated cytotoxicity, oxidative stress, activation of glial cells, increased intracellular calcium levels inflammatory responses and disruption of the blood-brain barrier (BBB). In addition, targeting specific miRNAs, therapeutic modulation of brain injury and apoptosis can also be achieved. Therefore, the current review has been compiled within an aim to give an overview of the developments exploiting miRNAs at different stages of stroke as prognostic, diagnostic, protective and therapeutic biomarkers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text