Global DNA methylation in earthworms: A candidate biomarker of epigenetic risks related to the presence of metals/metalloids in terrestrial environments
| Autor: | María Maldonado Santoyo, Katarzyna Wrobel, Kazimierz Wrobel, Adolfo Lopez Torres, Crescencio Rodríguez Flores |
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| Rok vydání: | 2011 |
| Předmět: |
Dose-Response Relationship
Drug Chemistry Health Toxicology and Mutagenesis Heavy metals General Medicine DNA Methylation Toxicology Pollution Epigenesis Genetic Metal Biomarker Metals visual_art Environmental chemistry DNA methylation visual_art.visual_art_medium Animals Soil Pollutants Metalloid Epigenetics Oligochaeta Biomarkers Environmental Monitoring Metalloids |
| Zdroj: | Environmental Pollution. 159:2387-2392 |
| ISSN: | 0269-7491 |
| Popis: | In this work, possible relationships between global DNA methylation and metal/metalloid concentrations in earthworms have been explored. Direct correlation was observed between soil and tissue As, Se, Sb, Zn, Cu, Mn, Ag, Co, Hg, Pb (p0.05). Speciation results obtained for As and Hg hint at the capability of earthworms for conversion of inorganic element forms present in soil to methylated species. Inverse correlation was observed between the percentage of methylated DNA cytosines and total tissue As, As + Hg, As + Hg + Se + Sb (β = -0.8456, p = 0.071; β = -0.9406, p = 0.017; β = -0.9526, p = 0.012 respectively), as well as inorganic As + Hg (β = -0.8807, p = 0.049). It was concluded that earthworms would be particularly helpful as bioindicators of elements undergoing in vivo methylation and might also be used to assess the related risk of epigenetic changes in DNA methylation. |
| Databáze: | OpenAIRE |
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