Immunological quantification of advanced glycosylation end-products in the serum of patients on hemodialysis or CAPD
| Autor: | Linda Grass, Eleftherios P. Diamandis, Athena Patrikarea, Helen Rodela, Panayiotis Papanastasiou, Dimitrios G. Oreopoulos |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Blood Glucose Glycation End Products Advanced medicine.medical_specialty Glycosylation medicine.medical_treatment urologic and male genital diseases Gastroenterology Nephropathy Peritoneal dialysis Immunoenzyme Techniques chemistry.chemical_compound Peritoneal Dialysis Continuous Ambulatory Renal Dialysis Diabetes mellitus Internal medicine medicine Animals Humans Aged Glycemic Creatinine business.industry Continuous ambulatory peritoneal dialysis Middle Aged medicine.disease Molecular Weight Diabetes Mellitus Type 1 Endocrinology Diabetes Mellitus Type 2 chemistry Nephrology Kidney Failure Chronic Advanced glycation end-product Female Rabbits Hemodialysis business |
| Zdroj: | Kidney International. 46:216-222 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/ki.1994.262 |
| Popis: | Immunological quantification of advanced glycosylation end-products in the serum of patients on hemodialysis or CAPD. We have developed an immunological procedure for measuring advanced glycosylation end-products (AGEs) in serum. Using this method, we measured AGEs in healthy volunteers, patients with diabetes, renal failure without treatment and in patients with renal failure, treated with hemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD). We found that AGEs were moderately elevated in diabetics without renal failure and highly elevated in CAPD and HD patients irrespective of their glycemie status. AGE levels correlated significantly with creatinine levels but not with levels of glucose or patient age or sex. AGE levels were reduced significantly post-hemodialysis. Preliminary experiments have shown that circulating AGEs have a molecular weight of approximately 1.5 to 2.0kDa. More studies are needed to establish if AGE measurements in serum are prognostic indicators of the complications of either diabetes or renal failure. |
| Databáze: | OpenAIRE |
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